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To help customers optimize clarification, Repligen has developed High Productivity Harvest, an alternative application using XCell ATF® technology that can provide more efficient clarification of high-density cultures, intensify harvest and displace depth filtration while keeping core operations in Fed Batch mode.

N-1 灌流


Using award-winning alternating tangential flow (ATF) technology, XCell ATF® cell retention devices deliver high cell concentration and process intensification during cell culture. Used with the N-1 bioreactor, it achieves exceptional high cell density in the seed train step, seeding the N production bioreactor at a higher starting cell density and shortening the production bioreactor run time.


High Productivity Harvest uses an XCell ATF® cell retention device after peak density is achieved in a typical Fed-Batch process. Fresh media is added in a set flow rate while the harvesting of the product is initiated. This results in significant productivity and process gains.