需求和挑战:
点击单元操作,查看您今天就能采用的产能及吞吐量提升解决方案。
![]() |
KrosFlo® TFDF™ 系统 |
---|
封闭式、一次性使用、自动化方案,可替代离心和初步深层过滤 慢病毒工艺的理想选择:提高产量、低剪切、低滞留体积 可从1L规模放大至2000L |
![]() |
SoloVPE™ 设备 |
---|
快速且准确的吸光度检测;避免费时费力且可能影响精确性的样品稀释操作 自动化质粒/病毒载体浓度检测,提高分析可变性和可重复性 |
Gene Therapy has immense potential to transform the lives of patients with genetic diseases. As demand for plasmids and viral vectors outpace capacity, a greater than 10-fold and potentially close to 100-fold increase in manufacturing efficiency for the gene therapy reagents is likely required to meet a demand curve that is increasing exponentially. Repligen solutions aim to meet the needs for optimized processes, higher yields, and improved process quality - setting new standards for modern scalable processes from gene to therapy.
具有基因治疗专业知识的 Repligen 现场应用专家 (FAS) 可为全球客户提供从咨询到操作的全方位支持。
Lentiviral vector manufacturing process enchancement utilizing TFDF™ technology
Thomas Williams、Oliver Goodyear、Lee Davies、Carol Knevelman、Michael Bransby、Kyriacos Mitrophanous & James Miskin
Cell and Gene Therapy Insights, 2020年4月
AAV Studies Deploying a Closed, Irradiated, Single-use Flat Sheet TFF Device
by David Bianchi, Carl Breuning, Michael LaBreck, Shelly Parra, Mary Jo Wojtusik, Repligen Corporation
Alex Meola, Michael Mercaldi, Thomas Thiers, Homology, Medicines Inc.
Repligen Corporation
Homology, Medicines Inc.
July 2020