ATF and TFF cell retention technologies were evaluated in our HDPB continuous process at lab and manufacturing scale. The filtration technologies were aligned at lab scale using common engineering criteria resulting in a comparable growth, productivity and product quality. A general overview of lessons learnt on the scalability, interchangeability and robustness at different scales will be given.
Joseph Shultz, Head-Biologics Technology & Innovation Strategy, Advanced Process and Manufacturing Technologies, Novartis Pharma
Ying Jing, Senior Strategy and Technology Leader, Cell Culture, Advanced Process and Manufacturing Technologies, Novartis Pharma
David joined Novartis in 2015 and has been actively contributing to the development and scale-up/scale-down of new upstream bioprocesses. Prior to that, he obtained his PhD degree in Chemical Engineering / Bioprocessing from Imperial College London (2014) and his MSc in Biochemical Engineering from TUDelft (2007).
His research interests lie in the area of mammalian cell bioprocessing, scale-up/down, mathematical modelling, data analysis and optimisation.