SARS CoV-2 specific affinity resin for the purification of COVID-19 vaccines


针对SARS CoV-2刺突蛋白纯化的新型亲和填料,用于疫苗开发和生产

The result of close work with Navigo Proteins on the ligand development and partnership with Purolite Life Sciences on Praesto®agarose bead technology, the new NGL COVID-19 Spike Protein Affinity Resin from Repligen binds the SARS CoV-2 Spike Protein receptor binding domain (RBD) to yield exceptional purity in a single chromatography step. The product meets all the expected requirements of a high-performance resin, including very high selectivity, high dynamic binding capacities and caustic stability over multi-cycle use.

The resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid implementation as well as in loose resin formats.


Single-step affinity chromatography with high resolution

NGL COVID-19刺突蛋白亲和填料的主要特点包括:

  • 含有SARS-CoV-2刺突蛋白RBD的产品的单步纯化*
  • 兼容 0.1N NaOH CIP
  • 高结合载量**
* Targets SARs CoV-2 spike protein variants containing the RBD. Examples include: S protein (S1/S2), S1 Protein, RBD, S Protein Trimer. Development data suggest that purification of whole inactivated virus, virus like particles (VLPs), and adenovirus may not yield satisfactory results.
**Actual DBC dependent on S protein variant & size

Optimized bead chemistry delivers exceptional purity

NGL COVID-19刺突蛋白亲和填料可在单个纯化步骤中获得>90%的纯度。

以HEK293细胞表达的SARS-CoV-2刺突蛋白受体结合结构域(RBD)以NGL COVID-19刺突蛋白亲和填料纯化的SDS-PAGE凝胶图。


Available pre-packed in OPUS® Columns for quick deployment


NGL COVID-19刺突蛋白亲和填料可以经质量确认的现货OPUS® 预装柱形式提供,以简化并加快GMP使用,同时,也提供“散装”填料形式。


OPUS® Pre-packed Columns

Manufacturing Centers of Excellence

Repligen在ISO 9001质量管理体系下开发和生产用于生物制药行业的产品。我们专注于及时交付高质量、一致且稳健的产品,以确保我们客户的业务连续性。

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany and Estonia.



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