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Solutions that work

Thursday, October 17, 2019   |   San Francisco, CA

Repligen technical seminars are unique opportunities to discuss the changing landscape of bioprocessing with key thought leaders and experts around the world. Industry case studies in process intensification, continuous processing and flexible facilities allow you to learn from adopters of transformative technologies, evaluate risk landscapes and set the standards for modern bioproduction.



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San Francisco Airport Hotel

1800 Old Bayshore Hwy
Burlingame, CA 94010




Avid BioServices commissioned a new commercial facility that exploits single-use and disposable technologies.  As part of this plan, Avid implemented the use of Repligen OPUS pre-packed columns in a multi-column process. Their use has led to reduced set-up time, reduced process time, reduced capital and validation expense.  This case study will describe the new facility and provide data demonstrating the positive impact of pre-packed columns in a multi-product manufacturing facility.   


seminar-driving-bioprocessing-efficiency-california-648cf4c9930114bd580d5ac5d7f4a2a8_f638.jpgDavid Briggs, Ph.D. is a Scientist in the Process Sciences department at Avid Bioservices.  In the Process Sciences department, Dave’s responsibilities include scaling-up and tech transfer of ultrafiltration, viral filtration, and chromatography steps from lab-scale to clinical and commercial scale.  Prior to working in Process Sciences, Dave worked as a downstream bioprocessing scientist in MS&T and downstream manufacturing associate in clinical manufacturing.  He received his Ph.D. in Molecular Biology & Biochemistry from the University of Arizona. 


In response to customers challenged with bioburden-sensitive TFF processes, technology leading single-use TangenX™ TFF flat sheet cassettes are now available in closed and irradiated format.  Used in ultrafiltration and diafiltration, the new cassettes come pre-assembled and pre-tested, using the same proprietary membrane choices and multiple MWCOs as SIUS™ flat sheet cassettes. This session will demonstrate how the new cassettes integrate easily into any process with faster turnaround time, improved productivity and lower risk of contamination.


Monica Amin.JPGMiss Amin is a Field Application Scientist in Repligen’s downstream FAS group. She has over 7 years of experience working in the biotech industry. She started her career working as an Applications R&D Engineer at Pall Corporation evaluating single use products (connectors, disconnectors, mixers, and TFF). She then went on to work at AbbVie Stemcentrx as an MSAT specialist on the manufacturing team. Here she gained experience on upstream, downstream and final fill manufacturing process of ADCs in a single use manufacturing facility, which included working with large scale single use TFF skids. She holds a Masters of Engineering degree in Chemical Engineering from Rensselaer Polytechnic Institute. 


An innovative ligand, NGL-Impact® A, developed by Repligen with Navigo through rigorous gene shuffling, screening and multimerization, is the basis of a new capture resin that rivals current industry standards. Partners in innovation, Repligen and Purolite used a proprietary jetting-based bead manufacturing process to develop the novel Protein A resin, Praesto® Jetted A50, that has been shown to deliver high capacity, caustic stability and bead uniformity. Potential economic benefits include decreased initial resin cost, extended resin lifetime, lower buffer usage and less operation time.


Purolite(HR)-0640-Chris.pngChris has 17 years biotechnology experience, having spent time with GE Healthcare, WAVE Bioreactors and Merck Millipore, advising clients on start-to-finish protein purification and MAb bioprocessing. At Purolite he leads the global commercial operations of the agarose division.


High Productivity Harvest (HPH) is a novel application developed by Repligen that enables you to harvest a fed batch bioreactor in a fully sterile manner while eliminating both centrifugation and depth filtration. A 0.2µm filtered, closed system and single step process using the XCell™ ATF System, HPH can significantly increase yields above industry standards and generate a sterile clarified batch harvest ready for either batch or continuous chromatography. This webinar will demonstrate how HPH works, present initial results of up to a 2-fold increase in protein production, and how you can apply HPH specific to your product need or facility design.  


jbcheadshot.jpgJohn joined Repligen during 2014 as part of the acquisition of Refine Technology where he was Vice President. He has developed and worked with different upstream technologies and, most recently, has propelled the XCell™ ATF System to become the dominant industry technology in continuous culture. Previously, he has founded or co-founded multiple companies in several countries in industries from newspapers to bioprocessing. John advises and speaks on small business coaching and entrepreneurship. John is a regular international speaker on bioprocessing. He is the editor of two editions of a book introducing Continuous Bioprocessing.


As a bioprocessing innovator with technology expertise in filtration, Repligen has developed a breakthrough clarification and harvest technology that can signal a paradigm shift in mAbs and Gene Therapy bioprocessing. A result of continuous innovation at Repligen, the solution integrates advances in multiple disciplines, combining novel polymer technology, various filtration modes, hardware, systems and automated process management. Potential benefits to productivity, product quality, yield and workflow efficiency will be discussed.


Parra, Shelly.jpgShelly Parra has over 20 years of experience in biotherapeutic process development, scale-up, technology transfer, manufacturing, and validation. She is currently the head of the global Field Applications team at Repligen and works with customers optimizing and scaling both upstream and downstream unit operations.  Prior to Repligen, Parra was employed at Thermo Fisher Scientific, Amgen, Transkaryotic Therapies, and BASF Bioresearch. She holds BS and MS degrees in Biotechnology from Worcester Polytechnic Institute in Massachusetts.


The 2000L Single Use Team needs a fully closed and single use harvest solution for 500L to 2000L volumes for the new end-to-end single use Clinical Supply Center build-out in Genentech South San Francisco to enable cost effective, flexible, faster technology transfer to different sites, and faster biopharmaceutical manufacturing. Traditional batch harvest historically has been performed with centrifugation and/or depth filtration to remove cell mass and further particle removal. Towards a fully closed and single use harvest process method, the team collaborated with the vendor to develop Tangential Flow Depth Filtration (TFDF), which was at its Beta testing stage in the first quarter of 2018. The effort focused on understanding the technology and establishing optimal filter properties for harvesting different molecules. Three different filtration scales were assessed.  CCF and permeate were analyzed for titer, yield, turbidity, lysis, product quality and impurities at the conclusion of each run. Identification of key filter properties, challenges encountered during evaluation, harvest performance data, and implementation plan will be discussed.