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SpectraFlo™ Dynamic Dialysis Systems

Introducing SpectraFlo™ Dynamic Dialysis Systems, the only commercially available systems for scalable dynamic dialysis from lab scale to large volume processing 

动态透析

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动态透析是一种令人振奋的新技术,其通过动态液流,来提高纯化效率,并优化大体积缓冲液的操作,是不稳定蛋白质、粘稠液体和聚合物凝胶(如透明质酸)纯化的理想选择。这种封闭式的高效系统可实现高浓度梯度的透析,而无需手动更换缓冲液以及过程中取样操作。

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SpectraFlo™ DYNAMIC DIALYSIS SYSTEMS

SpectraFlo™ Lab and Process Systems

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SpectraFlo™ Mobile Dialysis System

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continuous buffer flow

No manual buffer changes

Walkaway convenience

Fully INtegrated

Includes dialysis tank, pump, reservoirs, membrane

Fast implementation time

scale up, scale out

Scale up from lab to process scale.
Scale out from 1 to 6 tanks in series.

Increased purification efficiency

Sealed self-enclosed design

Minimized exposure to external contaminants

innovative mobile system 

Large-scale, small footprint

Series operation conserves buffer

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SpectraFlo™ Lab System

10-200 ml

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SpectraFlo™ Process System

150 ml - 2 L

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SpectraFlo™ Mobile System

6 - 12 L

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dynamic dialysis applications

Dynamic dialysis is ideal for the purification of viscous fluids and hydrogels (hyaluronic acid – HA) that cannot be filtered. Where traditional filtration methods may fail, dynamic dialysis uses flow dynamics to increase both the rate and efficiency of dialysis.

应用
Why Dynamic Dialysis is preferred
示例

Delicate samples

Gentle separation without shear stress

Labile proteins and intact viruses

Viscous samples (Hyaluronic Acid)

Process hydrogels that are too viscous for filtration

Cross-linked Hyaluronic Acid for aesthetics and orthobiologics

Protein refolding

Refold proteins to native state using gradual pH
change through buffer flow

Overexpressed proteins containing inclusion bodies

High debris lysate

Will not foul like pressure driven filtration

Demineralized bone matrix for othopedic surgery

Polymer and Biopolymer synthesis

Low MWCO enables removal of unbound low
molecular weight monomer

Oligonucleotides and polypeptides

Scale up of any static dialysis application

Easy scale up without complex validation or
financial burden of filtration

Desalting

 

Tank Sizes

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SpectraFlo™ MODES OF OPERATION

SpectraFlo™ modes of operation

Case Study: model of dynamic dialysis

This model of a GMP batch production of shear-sensitive protein shows an efficent scale-up of large volume dynamic dialysis for purification. 

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SpectraFlo™ MOBILE FEATURES AND BENEFITS

Features
福利

Up to 6 tanks in series

Scale up to 12L Sample Size

Parallel or series operation

Optimize buffer usage

Wet work tray

Prepare and load samples with secondary containment

Drain manifold

Load and drain buffer easily

BSE/TSE free polypropylene construction

Use for GMP processes and cleanroom manufacturing

Collapsible shelves and tubing hooks

Store complete system in compact space

 

透析膜

 

Repligen提供的透析膜包括生物技术级、标准级和定制化膜,可用于实验室规模和工艺规模操作。


DIALYSIS MEMBRANES

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Components and Accessories

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KR1 Peristaltic Pump

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600 RPM pump-drive with multi-position pump-head

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Processing Reservoirs

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Designed with drain and 4 ports for recirculating or reservoirs in series

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Bisectors

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Double sample capacity with 2 dialysis tubings in each tank. *Tank not included.

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Cap Kit

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Optional for process system, required for mobile system

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Replacement parts

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Pump tubing, gasket sets, hose barbs and stands

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Closure Kit

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For proper membrane handing and support
 

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资源

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