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NGL COVID-19 刺突蛋白亲和填料

Novel SARS CoV-2 specific affinity resin enables a high purity capture step, decreased process time, and yield improvement for the commercial production of COVID-19 vaccines.

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Icon_NEW.jpg sars CoV-2 特异性亲和填料

for the purification of COVID-19 vaccines

Novel affinity resin for the purification of the SARS CoV-2 Spike Protein for vaccine development and manufacturing

The result of close work with Navigo Proteins on the ligand development and partnership with Purolite Life Sciences on Praesto® agarose bead technology, the new NGL COVID-19 Spike Protein Affinity Resin from Repligen binds the SARS CoV-2 Spike Protein receptor binding domain (RBD) to yield exceptional purity in a single chromatography step. The product meets all the expected requirements of a high-performance resin, including very high selectivity, high dynamic binding capacities and caustic stability over multi-cycle use.

The resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid implementation as well as in loose resin formats.

Single-step affinity chromatography with high resolution

NGL COVID-19 Spike Protein Affinity Resin key features include:

  • 含有SARS-CoV-2刺突蛋白RBD的产品的单步纯化*
  • Compatible with 0.1N NaOH for CIP
  • High binding capacity **
* Targets SARs CoV-2 spike protein variants containing the RBD. Examples include: S protein (S1/S2), S1 Protein, RBD, S Protein Trimer. Development data suggest that purification of whole inactiviated virus, virus like particles (VLPs), and adenovirus may not yield satisfactory results.
**Actual DBC dependent on S protein variant & size

optimized bead chemistry delivers exceptional purity

NGL COVID-19 Spike Protein Affinity Resin delivers >90% purity in one chromatography step.

以HEK293细胞表达的SARS-CoV-2刺突蛋白受体结合结构域(RBD)以NGL COVID-19刺突蛋白亲和填料纯化的SDS-PAGE凝胶图。  

Available Pre-packed in OPUS® Columns for quick deployment

 

NGL COVID-19刺突蛋白亲和填料可以经质量确认的现货OPUS® 预装柱形式提供,以简化并加快GMP使用,同时,也提供“散装”填料形式。

使用预装、预质量确认的OPUS®层析柱,可使您在数周内从开发进入生产规模。

About OPUS® Columns