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Spectrum® Hollow Fiber Membranes

Repligen用于中空纤维过滤器组件的膜采用4种非均质结构的化学材质构造,完整封装于可抛弃型组件,可提供极高的通量、出色的分离性能,同时降低蛋白质结合,从而获得更高的产物产量。

 

Ultrafiltration (UF) membranes have a high density skin layer for less fouling and a fairly open outer support structure for increased filtration rates.

Microfiltration (MF) membranes have a retention defining microporous outer skin and a more open inner layer for increased filtration with higher recoveries.

Repligen在ISO 9001质量管理体系下开发和生产用于生物制药行业的产品。我们专注于及时交付高质量、一致且稳健的产品,以确保我们客户的业务连续性。

关于Repligen生产

Membrane Types

With a broad choice of single-use module configurations, hollow filter membranes from Repligen use advanced hydrophilic membrane filtration chemistry to provide higher flux rates for faster processing times, excellent selectivity for separation applications, and low protein binding for higher product yields than other membrane chemistries.

hollow fiber module configurations

 

  Membrane Fiber internal diameter MWCO and Pore Size # Module Configurations # Effective Lengths
           
mPES Modified Polyethersulfone 0.50 mm 1kD, 3kD, 5kD, 10kD, 30kD, 50kD, 70kD, 100kD, 300kD, 500kD, 750kD, 0.2µm 7 3
mPES Modified Polyethersulfone 0.75 mm 0.65µm 7 3
mPES Modified Polyethersulfone 1.00 mm 3kD, 5kD, 10kD 30kD, 50kD, 70kD, 100kD, 300kD, 500kD, 750kD 7 3
           
ME Mixed Cellulose Ester 0.63 mm 0.1µm, 0.2µm 7 3
ME Mixed Cellulose Ester 1.00 mm 0.2µm 7 3
           
PS Polysulfone  0.5 mm 10kD, 50kD, 500kD and 0.05µm 7 3
           
PES Polyethersulfone 0.5 mm 0.2µm 7 3
PES Polyethersulfone 1.0 mm 0.2µm 7 3

 

Membrane Applications

The following table shows typical use of membrane chemistries by application.

应用 Membrane selection mPES ME PS PES
Concentration and diafiltration (buffer exchange) of proteins, peptides, enzymes, recombinant proteins 1, 3, 5, 10, 30, 50, 70,100kD x   x  
Depyrogenation of water / buffers 3, 10kD x   x  
Coating, diafiltration, fractionation and/or dewatering of nanoparticles 70,100,300,500,750kD, 0.2µm x   x  
Concentration and diafiltration of albumin (nominal MW 67kd) 10kD x      
Concentration and diafiltration of monoclonal antibodies (155kd) 30kD x      
Concentration and diafiltration of envelope and non-envelope virus 50, 70, 100, 300, 500, 750kD, 0.05µm x   x  
Clarification of cell lysates, viral-expressed cultures to recover product in permeate 500, 750kD, 0.05, 0.1µm x x x  
Concentration and washing of insect, bacterial and/or
mammalian cells
750kD, 0.1, 0.2, 0.65µm x x    
Continuous bioreactor perfusion of cell culture 30, 50, 70, 100, 300, 500, 750kD, 0.2, 0.65µm x   x x
Concentration and diafiltration of single-stranded or double-stranded nucleic acids 1, 3, 5, 10, 30, 50, 70,100kD x      
Washing latex, polystyrene and other diagnostic particles to
remove un-reactives / unbound drug substance
500, 750kD, 0.05, 0.1, 0.2, 0.65µm x x x