TangenX™ SIUS™ Gamma filtration devices harness the performance and efficiencies of TangenX™ SIUS™ membranes and cassettes with the convenience of a fully assembled, closed and irradiated system.
PERFORMANCE TFF IN A CLOSED DEVICE WITH CONNECTION FREEDOM
TangenX™ SIUS™ Gamma filtration devices harness the performance and efficiencies of TangenX™ SIUS™ membranes and cassettes with the convenience of a fully assembled, closed and irradiated system.
Acclaimed performance with up to a 30% flux increase over conventional membranes, connectivity freedom and a library of molecular weight cutoffs, surface areas, chemistries and screen types converge into one, simple single-use flat-sheet solution. Manufactured under ISO 9001, every unit is integrity tested and quality tested.
Building closed systems can be challenging given the diversity of connectivity options available. TangenX™ SIUS™ Gamma Cassettes make your life easier by giving you connectivity choices. Either configure a ProConnex® flow path based on your specification, select a pre-built ProConnex® flow path that is ready-to-ship or simply plug the filtration device into your existing flow path with genderless AseptiQuik® connectors.
Repligen在ISO 9001质量管理体系下开发和生产用于生物制药行业的产品。我们专注于及时交付高质量、一致且稳健的产品，以确保我们客户的业务连续性。
CLAMP AND GO. IT'S THAT EASY.
The TangenX™ SIUS™ Gamma device arrives as a fully assembled closed device, including cassette, manifold, clamps, tubing and genderless AseptiQuik® connectors. Simply clamp into a holder, make your flow path connections and run your process.
Components
- Hex nut
- Washer
- 3. 2" or 1" tie-rod spacer(s)
- Holder top plate
- TangenX™ SIUS™ Gamma Cassette
- Manifold
- Holder bottom plate
Configured for you
Build a specification based flow path from a library of over 400 components with individual quality
testing.
Plug into existing
Leverage the flexibility of genderless connectors and seamlessly connect to your existing flow path.
Ready to Ship
Order a pre-built and quality tested off-the shelf ProConnex® flow path stocked for rapid delivery.
FIT FOR GENE THERAPY
Ideal for AAV processes where large volumes need to be concentrated 20-60X prior to chromatography
QUALITY MANUFACTURING
Manufactured in compliance with ISO guidelines in an ISO 7 clean room
Defined lead times
全球支持
Work with Repligen Field Applications Specialists from consultation to implementation
Tangenx™ Innovation Inside
- Same TangenX™ SIUS™ Flat Sheet Cassette membrane
- Single-cast membrane technology
- Selective pore sizes
- Clean flow path
- Efficient, precise cassette manufacturing
Diverse options for your diverse process needs
A wide selection of molecular weight cutoffs, surface areas, multiple chemistries and multiple screen types provide you with a library of options to address your diverse process requirements.
From sticky proteins to high concentration samples and from process development to manufacturing, the TangenX™ SIUS™ Gamma provides a closed solution. Scale, solve and move forward with one flat-sheet platform.
Membrane chemistries:
- ProStream® Membrane
- Neutrally balanced charge
- Low protein binding
- HyStream® Membrane
- Hydrophilic
- Low protein binding with minimal fouling with hydrophobic molecules
Screens:
观看网络研讨会
TangenX™ SIUS™ Gamma TFF cassettes incorporate the performance-leading TangenX™ TFF membrane and cassette manufacturing technologies into a closed, gamma-irradiated, single-use assembly. Genderless, aseptic connections easily integrate into your current UF/DF flow path, and a library of 64 MWCO and surface area configurations provide rich process options.
Equivalent performance with ready-to-use convenience
Seamless transition from TangenX™ SIUS™ Flat Sheet Cassette to TangenX™ SIUS™ Gamma Closed TFF Cassette
ProConnex® FLOW PATHS ADD FUNCTIONALITY AND CONVENIENCE
Custom ProConnex® Flow Paths complete your TFF solution
Custom
- Engineer-designed to customers’ specifications
- Choose from over 400 components
- connections
- process reservoirs
- pressure transducers
- aseptic connectors
Quality
- Individually inspected
- Integrity testing available
- Clean room assembled
- Double-bagged
Bioprocess Grade Materials
- Class VI
- BSE/TSE free
- Lot traceable
Clamp and go
- Complete flow path or drop-in tube sets
Validated Manufacturing
Quality Manufacturing
TangenX™ Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP. Each cassette comes with a Quality Assurance Certificate.
Comprehensive Regulatory Support Files
Each TangenX™ TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:
- Product information
- Cassette design
- Materials of construction
- Product performance
- Safety information
- Documentation system
- Product Manufacturing
- Qualification
- Manufacturing Process Validation
- Release Testing