KrosFlo KR2i and KrosFlo KMPi Flow Paths ​

The convenience of off-the-shelf flow paths designed specifically to run Spectrum® Hollow Fiber or TangenX® flat sheet cassettes on the KrosFlo KR2i and KMPi systems. Filter sold separately.

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Design Your Own​

Configure a KrosFlo KR2i or KrosFlo KMPi flow path to meet specific process requirements. Includes quality documentation and free consultation.​

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Custom KrosFlo KR2i ProConnex Flow Path

 

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You don’t mind the work of assembling your own flow path. Our selection of connectors, pressure sensors, tubing and vessels could be the solution for you.​

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KrosFlo FS-15 and FS-500 Flow Paths ​

Off-the-shelf flow paths offer convenience, reliability and quality documentation for flat sheet cassettes run on FS systems. No more cutting tubing, component searching, documentation and inconsistent setup. Filter sold separately.

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立即订购

Design Your Own​

Configure a FS flow path to meet specific process requirements. Includes quality documentation and free consultations.

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Custom KrosFlo KR2i ProConnex Flow Path

 

Order Parts

You don’t mind the work of assembling your own flow path. Our selection of connectors, pressure sensors, tubing and vessels could be the solution for you.​

立即订购

KrosFlo TFDF Lab Flow Paths

Off-the shelf, single-use, gamma-irradiated and closed TFDF Lab Flow Paths arrive dry, free of sodium hydroxide, glycerin, preservative and ethanol, for a zero flush start state.

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Custom KrosFlo TFDF Pilot and Process Flow Paths

When scaling up, configure a flow path to meet your process requirements for your pilot and process KrosFlo TFDF Systems. All KrosFlo TFDF flow paths are single-use, gamma-irradiated and arrive dry, free of sodium hydroxide, glycerin, preservative and ethanol, for a zero flush start state.

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KrosFlo KTF Flow Paths

Configure a flow path for either Spectrum Hollow Fibers or TangenX flat sheet cassettes that matches the design of your KrosFlo system.​

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KRM Chromatograhy System Flow Paths

Highly optimized, low hold-up volume flow paths that utilize innovative technologies like overmolded connections and injection molded intersections for optimal fluid dynamics on the advanced KRM Chromatography Systems.​

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KrosFlo RS TFF System Flow Path

Highly optimized, low hold-up volume flow paths that utilize innovative technologies like overmolded connections and injection molded intersections for optimal fluid dynamics on the highly automated KrosFlo RS Systems.​

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SYSTEM FLOW PATHS

Save time, streamline operations and hit the ground running

These off-the-shelf flow path solutions offered by Repligen deliver wins for the customers every step of the way.

 SYSTEM FLOW PATHS

High quality standard to minimize regulatory burden​ 

BIO USP <88> TSE/BSE

  • The fluid path of this single use fluid transfer system has passed USP class VI (USP<88>) and EMA/410/01

PARTICULATE USP <788>

  • Current USP standard for allowable visible and subvisible particulate for medical infusions an injections

ENDOTOXIN USP <85>

  • Current standard for quantification of endotoxin, Aqueous extracts from representatives samples contained <0.25 EU/mL

STERILITY ANSI/AAMI/ISO 11137

  • Validated following ANSI/AAMI/ISO 11137 guidelines for VDmax25 to provide a minimum sterility assurance level (SAL) for 10-6 for
CONFIGURABLE FLOW PATHS

Flow paths engineered to user specifications and requirements​

Leverage a library of over 300 individual components and expert support to turn specific process requirements into an optimal flow path in no time.​

Get the most out of the process and Repligen system while maintaining sterility and still being plug and play.

These custom configured flow path are supplied fully assembled, complete with accessories and filters.

Speak to an Expert

  CONFIGURABLE FLOW PATHS

Technical consultation from concept to product 

With decades of experience, Repligen technical experts match your core technology with the flow paths that suit your application.

Process goals
Core technology, application, facility fit

Process parameters
Feed flow rate​, working volume​ and pressure​, integrity test​, sterility​, scale

Flow path requirements
Aseptic connectors​, sensors​, vessel​, hold-up volume 

Flow path specifications
Engineering documents​, bill of materials​, design lock

High-Capacity, Globalized Manufacturing and Supply Chain​

A supply chain that prioritizes best-in-class lead times and 95% on time delivery by designing for robustness, redundancy and risk mitigation. System specific flow paths and certain hollow fiber filters are stocked and available off-the-shelf. ​

Membrane and module manufacturing

  • Multi-lane
  • Multi-site
  • Dual continent

Assembly and gamma radiation

  • Multi-lane, multi-site, and dual-continent assumbly centers
  • Multi-cell and multi-site gamma radiation with 2 independant partners

Packaging and logistics 

  • Continuous improvement programs
  • ISTA3A certified packaging process
  • Networked and regional distribution
  • Sustainability programs

Key Specifications for System Flow Paths​ 

Below are the key specifications for system flow paths. To see specifications for KrosFlo® KTF and RS TFF Systems or the KRM™ Chromatography System, please contact a sales representative.​

DescriptionHollow Fiber Ready KR2i Tube Sets Flat Sheet Ready KR2i Tube sets FS-15 Flat Sheet Ready Flow Paths FS-500 Flat Sheet Ready Flow Paths
系统KR2i KR2i FS15 FS500
Compatible withHF Modules C, D, T, S TFPLS-SA08 & TFPLS-LVFL - -
FPI Connectors- - 1/2" TC 1 - 1/2" TC
Reservoir Connectors - - 1/2" TC 1/2" TC
Reservoir Size 15 mL - 1 L 250 mL - 2 L - -
Pump Tubing (Feed, Addition) Pharmapure #14 - #25 Pharmapure #16 - #25 Silicone #17; #25; Reinforced .25" ID Silicone #82; #36; Reinforced .50" ID
Retentate and Permeate Tubing Silicone #14 - #25 Pharmapure #16 - #25 Silicone #17 & Reinforced Silicone 0.25" ID Silicone #82; #26; Reinforced Silicone 0.5" ID
Delivery Condition 无菌性 Irradiated Non-irradiated Non-irradiated
Hold-up Volume 0.3 mL - 40 mL 5 mL - 60 mL 75 mL 300 mL
产品编号 STUBEGN16315N STUBEGN16316N
ProConnex TFDF Flow Path实验室规模 实验室规模实验室规模Pilot-scale 工艺规模
类型过滤器 Flow path Flow path Flow path Flow path
Surface Area (cm2)3、30 3、30、50 150 450、750、1500 2100、6000
Fibers1 1 1 3、5、10 14、40
Total Fiber Length (cm) 20 20、36 108 108 108
有效长度 (cm) 2、20 2、20、36 108 108 108
Number of Tubes 1 1 1 3、5、10 14、40
Standard configuration made to stock
Customizable N/A
产品编号 TFDF-3, TFDF-30 STFDFCL15110S, STFDFCL15546S, STFDFCL15111S STFDFCL15112S - -

Manufacturing Centers of Excellence

Repligen在ISO 9001质量管理体系下开发和生产用于生物制药行业的产品。我们专注于及时交付高质量、一致且稳健的产品,以确保我们客户的业务连续性。

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany and Estonia.

地点

客户至上。

Repligen DNA 为您提供支持。我们的目标是提供卓越的客户体验,并为所有 Repligen 产品和服务高效成功的采用及实施提供支持。

  • Field Application Support
  • 客户服务
  • 现场服务工程师

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