ATF :: Repligen

Simplify and intensify upstream bioprocessing. The XCell ATF^® System, in single-use or stainless steel format, delivers high cell retention.

简化并强化细胞培养

Using award-winning alternating tangential flow (ATF) technology, XCell ATF^® cell retention devices deliver high cell concentration and process intensification during cell culture.

2种形式：一次性使用和不锈钢
用于单抗和重组蛋白灌流生产的领导性设备
适用于除灌流外的不同应用 - N-1灌流、高产量收获

ATF工作原理

屡获嘉奖的ATF技术

The XCell ATF^® System is based on award-winning alternating tangential flow (ATF) technology, created by the action of a diaphragm moving upward and downward within a pump head, connected to a filter housing and attached to a bioreactor. Alternating tangential flow is attained by the action of a diaphragm pump.

XCell ATF^® formats

XCell ATF^® - Single-use

100%细胞截留，安装加快80%，无需高压灭菌

The XCell ATF^® Single-use System comes in multiple sizes from lab-scale to production-scale. Each system consists of a single-use device, a single-use hollow fiber filter cartridge, and a control system.

XCell ATF^® - Stainless Steel

100%细胞截留，高细胞密度和产物产量

The XCell ATF^® System in stainless steel comes in multiple sizes from lab-scale to production-scale. Each system consists of a diaphragm pump in a stainless steel housing, a single-use hollow fiber filter cartridge, and a control system.

连续性

实现连续工艺，获得可直接用于捕获层析的澄清收获液

高性能

100%细胞截留，高细胞浓度和活性；可连接任何生物反应器，实现不同应用目的

独特设计

温和作用过程，降低细胞应激，提高细胞活性和产率；自清洁，降低积聚在中空纤维过滤器上的生物薄膜

一次性使用形式

节省高达80%的安装时间，无需高压灭菌

可放大性

从工艺开发规模到生产规模

全球支持

现场应用和客服专员，提供全球化的支持

Repligen在ISO 9001质量管理体系下开发和生产用于生物制药行业的产品。我们专注于及时交付高质量、一致且稳健的产品，以确保我们客户的业务连续性。

关于Repligen生产

灌流和补料分批应用

长期灌流

Perfusion, or upstream continuous processing, has been used since the 1980s. High cell density perfusion with XCell ATF^® devices delivers higher cell concentration and cell viability.

补料分批：
N-1灌流