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XCell ATF®

Simplify and intensify upstream bioprocessing. The XCell ATF® System, in single-use or stainless steel format, delivers high cell retention. 

简化并强化细胞培养

Using award-winning alternating tangential flow (ATF) technology, XCell ATF® cell retention devices deliver high cell concentration and process intensification during cell culture. 

  • 2种形式:一次性使用和不锈钢
  • 用于单抗和重组蛋白灌流生产的领导性设备
  • 适用于除灌流外的不同应用 - N-1灌流、高产量收获

ATF工作原理

屡获嘉奖的ATF技术

 

The XCell ATF® System is based on award-winning alternating tangential flow (ATF) technology, created by the action of a diaphragm moving upward and downward within a pump head, connected to a filter housing and attached to a bioreactor. Alternating tangential flow is attained by the action of a diaphragm pump.

XCell ATF® formats

XCell™ ATF 一次性使用系统

XCell ATF® - Single-use 

100%细胞截留,安装加快80%,无需高压灭菌

The XCell ATF® Single-use System comes in multiple sizes from lab-scale to production-scale. Each system consists of a single-use device, a single-use hollow fiber filter cartridge, and a control system.

XCell™ ATF 系统 - 不锈钢

XCell ATF® - Stainless Steel

100%细胞截留,高细胞密度和产物产量

The XCell ATF® System in stainless steel comes in multiple sizes from lab-scale to production-scale. Each system consists of a diaphragm pump in a stainless steel housing, a single-use hollow fiber filter cartridge, and a control system.

连续性

实现连续工艺,获得可直接用于捕获层析的澄清收获液

高性能

100%细胞截留,高细胞浓度和活性;可连接任何生物反应器,实现不同应用目的

独特设计

温和作用过程,降低细胞应激,提高细胞活性和产率;自清洁,降低积聚在中空纤维过滤器上的生物薄膜

一次性使用形式

节省高达80%的安装时间,无需高压灭菌

可放大性

从工艺开发规模到生产规模

全球支持

现场应用和客服专员,提供全球化的支持

Repligen在ISO 9001质量管理体系下开发和生产用于生物制药行业的产品。我们专注于及时交付高质量、一致且稳健的产品,以确保我们客户的业务连续性。

关于Repligen生产

灌流和补料分批应用


长期灌流

Perfusion, or upstream continuous processing, has been used since the 1980s. High cell density perfusion with XCell ATF® devices delivers higher cell concentration and cell viability.

补料分批:
N-1灌流

N-1灌流是指对生产N生物反应器之前N-1生物反应器中细胞生长的强化,其仍为补料分批模式。该工艺可实现生产生物反应器的高细胞密度接种。

补料分批:
高产量收获

高产量收获(HPH)是Repligen开发的一种新的应用,可帮助您以完全无菌的方式收获补料分批生物反应器,同时消除离心和深层过滤步骤。

资源

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常见问题 | 灌流