Configurability and Compliance for Automated TFF up to 500L

Configurability and Compliance for Automated TFF up to 500L

Driven by the rise in cell and gene therapies, TFF unit operations at scales from 10 mL to 500 L now require the single-use, automation and data integrity capabilities previously reserved for larger scale systems. The newly developed KrosFlo® KMPi TFF System from Repligen provides walk-away automation for concentration, diafiltration and fed-batch processes with TMP control, closed and single-use flow paths and 21 CFR Part 11 software compliance for processes up to 500L. Key components to this new system include: a patented automatic back-pressure control valve, a proprietary control board that enables plug-and-play hardware connectivity and modern software built upon a secure SQL database. Key technical features and applications supported by flexible configurations of the KrosFlo® KMPi TFF System will be discussed.