TangenX® SIUS® Single-use TFF Cassettes are a convenient alternative to reusable cassettes. Delivered ready to use with choice of membrane, pore size and flow-channel configuration, SIUS Cassettes enable cost and process efficiencies while eliminating tedious clean-in-place (CIP) and sanitization steps. 

播放图标 视频海报

Unparalleled process and cost efficiencies

TangenX® SIUS® Single-use Cassettes are the first purpose-built cassettes designed for tangential flow filtration. Deploying these innovative cassettes can help reduce filter cost by 80%, reduce labor costs by 50%, and reduce buffer and water usage by 75% when compared to traditional reusable cassettes.



Simple connectivity with ProConnex® Flow Paths

Custom ProConnex® Flow Paths complete your TFF solution. Flow paths are build using Class VI Bioprocess-grade materials that are BSE/TSE-free and Lot-traceable.



Build a custom flow path to your specifications

  • Engineer-designed 
  • 可从超250种部件的物料库中进行选择
    • 接头
    • 工艺容器
    • 压力传感器
    • 无菌接头

Order a pre-built and quality tested off-the shelf ProConnex® Flow Path stocked for rapid delivery.

  • 单个独立检测
  • 可提供完整性检测 
  • 洁净室组装
  • 双层包装袋包装



Diverse options for diverse process needs

SIUS® TFF Cassettes are offered with two membrane chemistries, two screen types, a wide selection of molecular weight cutoffs (MWCO), and a broad range of surface areas. With 96 configurations available, SIUS  TFF Cassettes accommodate diverse process requirements for ultrafiltration and diafiltration applications from process development to commercial manufacturing.

ProStream Membrane

  • 中性电荷
  • 低蛋白结合
  • 出色的化学耐受性

HyStream Membrane

  • 亲水性
  • 低蛋白结合
  • 疏水性物质污染最小化

Multiple channel configurations

Tangential flow filtration cassettes create turbulence at the membrane's surface and minimize fouling. The result is an increase in performance with a higher permeate flux. SIUS® Cassettes are offered in three different channel configurations to best suit the application. The channel configuration refers to the type of turbulence promoter incorporated into the feed channel of a cassette.


A medium channel or L screen is offered in all TangenX® SIUS® Cassette formats. The screen creates turbulence at the membrane's surface ensuring outstanding permeate flux with minimal fouling. This channel configuration requires the lowest pumping rate and yields the highest cross flow velocity. This type of channel is best suited for clarified feed streams over a wide range of viscosities.


A coarser screen channel, the EP channel is offered in all TangenX® SIUS® Cassettes. The screen geometry of this single-use cassette can process feed streams with a higher viscosity and reduce the overall pressure drop. It is scalable from 100cm2 to 2.5m2, packaged sanitized and compatible with existing cassette holders and FPIs. This type of channel is best suited for processes that use shear sensitive feed streams.


An open channel or J channel is offered in all TangenX® SIUS® Cassettes. A 0.5mm flow spacer separating the membrane creates an open feed flow channel. This type of channel creates the least amount of turbulence while still minimizing fouling. It also requires the highest pumping rate to pass particulates. This type of channel is best suited for unclarified feed streams and is used for processes such as cell harvest operation.


Compatible with most cassette holders

To ensure fit with cassette holders from other manufacturers, SIUS® TFF Cassettes for process development are offered with two different notch patterns at the end of the cassette.


TangenX® SIUS® PD with standard notch
0.850in (21.59mm) Offset


  • TangenX® SIUS® PD Cassette Clamps
  • TangenX® PRO PD Cassette Holders
  • Pall - Centramate 夹具 (CM018LV、FS001K10)

TangenX® SIUS® PD with offset notch
0.756in (19.21mm) 偏置


  • 这种构型可匹配以下第三方膜包夹具:
  • Sartorius - Sartocon Slice 夹具 (17525-01、17521-02)
  • GE - Kvick Lab 夹具 (KLPH01SSU、KLHR0105000SS)
  • Millipore - Pellicon Mini 夹具 (XX42PMINI)


Process volume and membrane area determine scale-up from SIUS® Single-use Cassettes to PRO Reusable TFF Cassettes.



Single-use TFF provides the greatest benefit for small to moderate scale operations.
Reusable TFF is optimal for large production scale operations.

Interested in simulating a cost model for your specific application?

SIUS® Gamma Devices for sterile processes

SIUS® Gamma Devices embody the performance and efficiency of SIUS Cassettes in a convenient, fully assembled, closed, and sterile system. ​Acclaimed performance with up to 30% flux increase over conventional membranes, connectivity freedom, and a library of configurations, converge into one, simple TFF solution. ​SIUS Gamma TFF Devices are ideal for gene therapy applications, bioburden-sensitive operations, and hazardous processes. 

SIUS Gamma Devices

TangenX® SIUS® Cassettes

 Validated for GMP use, SIUS® TFF Cassettes are delivered ready to use with either ProStream or HyStream membranes, with choice of pore sizes and flow-channel configurations. Pre-sanitized and packaged with 0.2M NaOH, the cassettes are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up. 

Click on the tabs below to explore different features of SIUS Cassettes for process development or commercial manufacturing.

During process development, the aim is to select the most promising membrane candidates while making related decisions regarding feed pressure,  trans-membrane pressure (TMP) and screen geometry. SIUS® PD Single-use TFF Cassettes save valuable time and resources by eliminating cleaning cycles between experiments. Designed for processing volumes from tens of milliliters to several liters, SIUS PD Cassettes enable linear scale processing over a wide range of operating volumes.


Membrane Surface Areas:
0.01 meter2, 0.02 meter2, 0.10 meter2

When the primary membrane candidate has already been chosen as a process parameter, the production method needs to be verified and production materials produced for toxicology or pre-clinical trials, and ultimately for large-scale commercial production. SIUS® Single-use TFF Cassettes provide reliable cassette-to-cassette consistency, ensuring that processes can scale to commercial production levels.


Membrane Surface Areas:
0.5 meter2, 1.5 meter2, 2.5 meter2

R 因子视频博客

Manufacturing Centers of Excellence

Repligen在ISO 9001质量管理体系下开发和生产用于生物制药行业的产品。我们专注于及时交付高质量、一致且稳健的产品,以确保我们客户的业务连续性。

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany and Estonia.


Validated manufacturing


TangenX® Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP. Each cassette comes with a Quality Assurance Certificate. 


Each TangenX® TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:

  • 产品信息
  • 膜包设计
  • 结构材料
  • 产品性能
  • 安全信息
  • 文件系统
  • 产品生产
  • 质量确认
  • 生产工艺验证
  • 出厂检测


Repligen DNA 为您提供支持。我们的目标是提供卓越的客户体验,并为所有 Repligen 产品和服务高效成功的采用及实施提供支持。

  • Field Application Support
  • 客户服务
  • 现场服务工程师