TangenX® SIUS® Gamma TFF Devices
With the performance and efficiency of SIUS® Cassettes, SIUS Gamma Devices come as a convenient, fully assembled, closed, and sterile system.
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Achieve higher flux, closed device and connectivity freedom
TangenX® SIUS® Gamma TFF Devices embody the performance and efficiency of SIUS® Cassettes in a convenient, fully assembled, closed, and sterile system. Acclaimed performance with up to 30% flux increase over conventional membranes, connectivity freedom, and a library of configurations, converge into one, simple TFF solution. SIUS Gamma TFF Devices are ideal for gene therapy applications, bioburden-sensitive operations, and hazardous processes.
READY-TO-USE
Clamp-and-go connectivity
The diversity of connectivity options makes building closed systems a challenge. Genderless AseptiQuik® connectors featured on TangenX® SIUS® Gamma TFF Devices make life easier. Simply clamp the SIUS® Gamma TFF Device into a holder, connect to a flow path, and go. It's that easy.
Click on the links below to explore how to assemble SIUS Gamma TFF Devices. TangenX® SIUS® hardware may be purchased separately.
READY-TO-USE
Simple connectivity with ProConnex® Flow Paths
Custom ProConnex® Flow Paths complete your TFF solution. Flow paths are build using Class VI Bioprocess-grade materials that are BSE/TSE-free and Lot-traceable.
CONFIGURED FOR YOU
Build a custom flow path to your specifications
- Engineer-designed
- 可从超250种部件的物料库中进行选择
- 接头
- 工艺容器
- 压力传感器
- 无菌接头
READY TO SHIP
Order a pre-built and quality tested off-the shelf ProConnex® Flow Path stocked for rapid delivery.
- 单个独立检测
- 可提供完整性检测
- 洁净室组装
- 双层包装袋包装
PLUG INTO EXISTING
采用无公母头区分的灵活快接头，可无缝连接至您现有的流路。
HIGH PERFORMANCE
相当的性能，而兼具即取即用的便利性
Transition from SIUS® Cassettes to SIUS® Gamma TFF Devices seamlessly.
膜性能不受暴露于伽马辐照的影响。
When comparing performance of TangenX® SIUS® Cassettes (solid line) and TangenX® SIUS® Gamma TFF Devices (dashed line):
- 滤液通量相当
- BSA 截留差异小于1 %
HIGH PERFORMANCE
Diverse options for diverse process needs
TangenX® SIUS® Gamma TFF Devices are offered with two membrane chemistries, two screen types, a wide selection of molecular weight cutoffs (MWCO), and a broad range of surface areas. With 96 configurations available, TangenX® SIUS® Gamma TFF Devices accommodate diverse process requirements for ultrafiltration and diafiltration applications from process development to commercial manufacturing.
- 中性电荷
- 低蛋白结合
- 出色的化学耐受性
- 亲水性
- 低蛋白结合
- 疏水性物质污染最小化
Screens
READY TO SCALE FAST
Scalable from lab to process scale
TangenX® SIUS® Gamma Devices scale from process development to large-scale manufacturing. Molecular weight cut-offs (MWCO)s extend from 10 kD up to 100 kD. Mermbrane area range from 0.1 - 10 m2.
截留分子量
10 kD, 30 kD, 50 kD, 100 kD
Membrane area
0.1, 0.5, 1.5, 2.5, 5, 10 m2
TangenX® SIUS® Gamma Devices
TangenX® SIUS® Gamma TFF Devices incorporate the performance-leading TangenX® TFF membrane and cassette manufacturing technologies into a closed, gamma-irradiated, single-use assembly. Genderless, aseptic connections easily integrate into your current UF/DF flow path.
Click on the links below to explore different features.
Ohhhh, 一个响指的工夫!
In a snap, you can build a closed TangenX® SIUS® Gamma flow path. It’s that easy.
TangenX® SIUS® Gamma TFF Devices incorporate the performance-leading TangenX® TFF membrane and cassette manufacturing technologies into a closed, gamma-irradiated, single-use assembly. Genderless, aseptic connections easily integrate into your current UF/DF flow path.
Validated manufacturing
高质量生产
TangenX® Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP. Each cassette comes with a Quality Assurance Certificate.
完整法规支持文件
Each TangenX® TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:
- 产品信息
- 膜包设计
- 结构材料
- 产品性能
- 安全信息
- 文件系统
- 产品生产
- 质量确认
- 生产工艺验证
- 出厂检测
客户至上。
Repligen DNA 为您提供支持。我们的目标是提供卓越的客户体验，并为所有 Repligen 产品和服务高效成功的采用及实施提供支持。
- Field Application Support
- 客户服务
- 现场服务工程师
KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
TangenX® SIUS® TFF Cassettes
SIUS® Cassettes are the first purpose-built single-use cassettes for tangential flow filtration, delivering unparalleled savings in filter cost, labor cost and buffer use.
TangenX SC TFF Device
TangenX® SC TFF Device: Revolutionize tangential flow filtration processes
Eliminate the hassle and inefficiency that comes with traditional downstream filtration cassette formats. Say goodbye to cassette holders, complex setups, continued torquing, wasted time, and product loss risks. Discover TangenX® SC, the future of TFF cassette solutions for ultrafiltration and diafiltration, designed to meet the demands of today’s TFF processes while dramatically reducing setup time and minimizing product loss risk.
资源
by David Bianchi, Carl Breuning, Michael LaBreck, Shelly Parra, Mary Jo Wojtusik, Repligen Corporation
Alex Meola, Michael Mercaldi, Thomas Thiers, Homology, Medicines Inc.
Repligen Corporation
Homology, Medicines Inc.
2020年7月
