MAXIMIZED PERFORMANCE

Gentle on shear-sensitive molecules

Hollow fibers possess a smooth internal wall and tubular channel geometry, that promotes laminar flow with high flux. The low shear and turbulence of laminar flow helps maintain the integrity of shear sensitive modalities such as lentivirus.

Laminar flow

Flow is primarily straight and streamlined

 

Turbulent flow

Irregular, chaotic flow creates eddies that change flow in both magnitude and direction

 MAXIMIZED PERFORMANCE

Game-changing mPES Chemistry

Directly modified from the PES backbone

  • Uniquely formulated to provide tight selectivity without sacrificing high flux
  • Thin selective layer in the inner lumen​​
  • Significantly s more porous membrane​​
  • Robust design for high-pressure applications​​
  • Ideal for Lentivirus, mRNA, pDNA and LNPs​​
  • Maximizes recovery
  • Reduces fouling

Find your filter configuration          申请报价

 

 

膜应用

下表所示为不同膜材质过滤器的典型应用

应用 膜选择 mPES PES ME PS
Concentration and diafiltration (buffer exchange) of proteins, peptides, enzymes, recombinant proteins 3, 5, 10, 30, 50, 70,100kD x x
水 / 缓冲液除热源 3, 10kD x x
纳米颗粒包被、洗滤、分馏和/或脱水 70,100,300,500,750kD, 0.2µm x x
白蛋白(标称分子量67kd)浓缩和洗滤 10kD x
单克隆抗体(155kd)浓缩和洗滤 30kD x
有囊膜和无囊膜病毒浓缩和洗滤 50, 70, 100, 300, 500, 750kD, 0.05µm x x
细胞裂解液、表达病毒的培养液澄清,回收滤液中的产物 500, 750kD, 0.05, 0.1µm x x x
Concentration and washing of insect, bacterial and/or mammalian cells 750kD, 0.1, 0.2, 0.5, 0.65µm x x x
生物反应器连续细胞灌流培养 30, 50, 70, 100, 300, 500, 750kD, 0.2, 0.65µm x x
单链或双链核酸浓缩和洗滤 3, 5, 10, 30, 50, 70,100kD x
Washing latex, polystyrene and other diagnostic particles to remove un-reactives / unbound drug substance 500, 750kD, 0.05, 0.1, 0.2, 0.65µm x x x
 EMPHASIS ON EFFICIENCY

Emphasis on manufacturing innovation and security of supply
 

State-of-the-art facility

  • ISO 9001 certified
  • ISO 7 cleanroom

High degree of automation

  • Hight throughput
  • Consistency in quality

Competitive lead times

  • Select off-the-shelf filters
  • Available with or without gamma irradiation
  END-TO-END EXPERTISE

Leverage TFF expertise in filter selection and beyond

  • Selection of TFF format: Heavily reliant on modality
  • Screening membrane MWCO: Selection based on recovery and impurity removal
  • Final TFF condition optimization and sizing for process scale-up: Flux optimization and sizing at different scales

咨询专家

规模放大更加简单

中空纤维过滤器组件提供多种尺寸、表面积和膜材质选择,可轻松实现从小体积工艺开发和R&D应用到商品化生产的规模放大。规模放大时,维持过滤流路长度,增加纤维数量,即可提高过滤器的表面积,从而处理更大体积的料液。

  主要应用 体积 进口 / 出口 侧面
端口
有效长度 (cm) Total Length (cm) Surface area

MicroKros

             

立即订购

Process characterization, Small-volume TFF in a laboratory 1-100 mL MLL FLL 20
41.5
65
25
45
69
13 – 20 cm2
26 - 59 cm2
41 - 92 cm2

MidiKros

             

立即订购

小规模工艺开发 100mL - 3L FLL FLL 20
41.5
65
25
45
69
75 – 190 cm2
155 - 390 cm2
245 - 610 cm2

MidiKros TC

             

立即订购

中试规模工艺开发 100mL - 3L 1/2" TC FLL 20
41.5
65
25
45
69
75 – 190 cm2
155 - 390 cm2
245 - 610 cm2

MiniKros Sampler

             

立即订购

小体积批量TFF 3 L -15 L 0.75" TC 0.75" TC 20
41.5
65
25
47
70
490 – 1000 cm2
1000 - 2200 cm2
1600 - 3400 cm2

MiniKros

             

 申请报价

中试规模TFF 5 L - 50 L 1.5" TC 0.75" TC 20
41.5
65
25
46
70
0.16 - 0.31 m2
0.32 - 0.65 m2
0.51 - 1.0 m2

KrosFlo®

             

申请报价

生产规模TFF 10 – 100L 3" TC 1.5" TC 20
41.5
65
23
46
69
0.78 - 1.6 m2
1.65 - 3.25 m2
2.55 - 5.10 m2

KrosFlo® MAX

             
申请报价 生产规模TFF 100L – 1000+L 6" TC 1.5" TC 49.9
67.9
107.5
73.5
91.5
131.1
4.30 - 10.40 m2
7.10 - 17.10 m2
11.30 - 11.35 m2

配置器

Find a Spectrum Hollow Fiber Filter

Search for Spectrum Hollow Fiber Filters by Module Family, Membrane Chemistry, MWCO, and other parameters.

Hollow Fiber Calculator

Easy-to-use online Hollow Fiber Filter tool for calculating critical process parameters like Flow Rate Per Fiber, Holdup Volume, Total Surface Area, and more.

产品编号规则

To specify the hollow fiber filter specific to your application, follow the product number key below.

Click on the image highlights to see the different elements of lab-scale and commercial-scale TFF Solutions from Repligen

Complete lab-scale TFF Solution from Repligen

Complete commercial-scale TFF Solution from Repligen

资源