中空纤维过滤器
用于切向流过滤的可抛弃型中空纤维过滤器完整封装于外壳内,可耐受较高压力,同时提供多种纤维材质和尺寸选择,且可从工艺开发规模放大至生产,是超滤、洗滤和微滤的理想选择。
Maximized performance
Gentle on shear-sensitive product
Emphasis on Efficiency
MAXIMIZED PERFORMANCE
Gentle on shear-sensitive molecules
Hollow fibers possess a smooth internal wall and tubular channel geometry, that promotes laminar flow with high flux. The low shear and turbulence of laminar flow helps maintain the integrity of shear sensitive modalities such as lentivirus.
Laminar flow
Flow is primarily straight and streamlined
Turbulent flow
Irregular, chaotic flow creates eddies that change flow in both magnitude and direction
MAXIMIZED PERFORMANCE
Game-changing mPES Chemistry
Directly modified from the PES backbone
- Uniquely formulated to provide tight selectivity without sacrificing high flux
- Thin selective layer in the inner lumen
- Significantly s more porous membrane
- Robust design for high-pressure applications
- Ideal for Lentivirus, mRNA, pDNA and LNPs
- Maximizes recovery
- Reduces fouling
Find your filter configuration 申请报价
膜应用
下表所示为不同膜材质过滤器的典型应用
EMPHASIS ON EFFICIENCY
Emphasis on manufacturing innovation and security of supply
State-of-the-art facility
- ISO 9001 certified
- ISO 7 cleanroom
High degree of automation
- Hight throughput
- Consistency in quality
Competitive lead times
- Select off-the-shelf filters
- Available with or without gamma irradiation
END-TO-END EXPERTISE
Leverage TFF expertise in filter selection and beyond
- Selection of TFF format: Heavily reliant on modality
- Screening membrane MWCO: Selection based on recovery and impurity removal
- Final TFF condition optimization and sizing for process scale-up: Flux optimization and sizing at different scales
规模放大更加简单
中空纤维过滤器组件提供多种尺寸、表面积和膜材质选择,可轻松实现从小体积工艺开发和R&D应用到商品化生产的规模放大。规模放大时,维持过滤流路长度,增加纤维数量,即可提高过滤器的表面积,从而处理更大体积的料液。
主要应用 | 体积 | 进口 / 出口 | 侧面 端口 |
有效长度 (cm) | Total Length (cm) | Surface area | |
---|---|---|---|---|---|---|---|
MicroKros |
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Process characterization, Small-volume TFF in a laboratory | 1-100 mL | MLL | FLL | 20 41.5 65 |
25 45 69 |
13 – 20 cm2 26 - 59 cm2 41 - 92 cm2 |
|
MidiKros |
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小规模工艺开发 | 100mL - 3L | FLL | FLL | 20 41.5 65 |
25 45 69 |
75 – 190 cm2 155 - 390 cm2 245 - 610 cm2 |
|
MidiKros TC |
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中试规模工艺开发 | 100mL - 3L | 1/2" TC | FLL | 20 41.5 65 |
25 45 69 |
75 – 190 cm2 155 - 390 cm2 245 - 610 cm2 |
|
MiniKros Sampler |
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小体积批量TFF | 3 L -15 L | 0.75" TC | 0.75" TC | 20 41.5 65 |
25 47 70 |
490 – 1000 cm2 1000 - 2200 cm2 1600 - 3400 cm2 |
|
MiniKros |
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中试规模TFF | 5 L - 50 L | 1.5" TC | 0.75" TC | 20 41.5 65 |
25 46 70 |
0.16 - 0.31 m2 0.32 - 0.65 m2 0.51 - 1.0 m2 |
|
KrosFlo® |
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生产规模TFF | 10 – 100L | 3" TC | 1.5" TC | 20 41.5 65 |
23 46 69 |
0.78 - 1.6 m2 1.65 - 3.25 m2 2.55 - 5.10 m2 |
|
KrosFlo® MAX |
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申请报价 | 生产规模TFF | 100L – 1000+L | 6" TC | 1.5" TC | 49.9 67.9 107.5 |
73.5 91.5 131.1 |
4.30 - 10.40 m2 7.10 - 17.10 m2 11.30 - 11.35 m2 |
配置器
产品编号规则
To specify the hollow fiber filter specific to your application, follow the product number key below.
Click on the image highlights to see the different elements of lab-scale and commercial-scale TFF Solutions from Repligen