中空纤维过滤器

Ideal for ultrafiltration and microfiltration of shear-sensitive modalities, Spectrum^® Hollow Fiber Filters for TFF can accommodate the widest range of scales, membrane chemistries and pore sizes to maximize process outcomes.

关于 Filter Formats 配置器资源

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Maximized performance

Gentle on shear-sensitive product

mPES membrane chemistry with tighter selectivity

4 membrane chemistries, 15 pore sizes available

Emphasis on Efficiency

Plug-and-play modules

Closed, once connected to flow path

Robust supply chain and fast delivery

End-to-end TFF Expertise

Support in selecting TFF format

Assistance in screening for MWCO

Final condition optimization and process scale-up

MAXIMIZED PERFORMANCE

Gentle on shear-sensitive molecules

Hollow fibers possess a smooth internal wall and tubular channel geometry, that promotes laminar flow with high flux. The low shear and turbulence of laminar flow helps maintain the integrity of shear sensitive modalities such as lentivirus.

Laminar flow

Flow is primarily straight and streamlined

Turbulent flow

Irregular, chaotic flow creates eddies that change flow in both magnitude and direction

MAXIMIZED PERFORMANCE

Game-changing mPES Chemistry

Directly modified from the PES backbone

Uniquely formulated to provide tight selectivity without sacrificing high flux
Thin selective layer in the inner lumen
Significantly s more porous membrane
Robust design for high-pressure applications
Ideal for Lentivirus, mRNA, pDNA and LNPs
Maximizes recovery
Reduces fouling

Find your filter configuration 申请报价

膜应用

下表所示为不同膜材质过滤器的典型应用

应用	膜选择	mPES	PES	ME	PS
Concentration and diafiltration (buffer exchange) of proteins, peptides, enzymes, recombinant proteins	3, 5, 10, 30, 50, 70,100kD	x			x
水 / 缓冲液除热源	3, 10kD	x			x
纳米颗粒包被、洗滤、分馏和/或脱水	70,100,300,500,750kD, 0.2µm	x	x
白蛋白（标称分子量67kd）浓缩和洗滤	10kD	x
单克隆抗体（155kd）浓缩和洗滤	30kD	x
有囊膜和无囊膜病毒浓缩和洗滤	50, 70, 100, 300, 500, 750kD, 0.05µm	x			x
细胞裂解液、表达病毒的培养液澄清，回收滤液中的产物	500, 750kD, 0.05, 0.1µm	x		x	x
Concentration and washing of insect, bacterial and/or mammalian cells	750kD, 0.1, 0.2, 0.5, 0.65µm	x	x	x
生物反应器连续细胞灌流培养	30, 50, 70, 100, 300, 500, 750kD, 0.2, 0.65µm	x	x
单链或双链核酸浓缩和洗滤	3, 5, 10, 30, 50, 70,100kD	x
Washing latex, polystyrene and other diagnostic particles to remove un-reactives / unbound drug substance	500, 750kD, 0.05, 0.1, 0.2, 0.65µm	x		x	x

EMPHASIS ON EFFICIENCY

Emphasis on manufacturing innovation and security of supply

State-of-the-art facility

ISO 9001 certified
ISO 7 cleanroom

High degree of automation

Hight throughput
Consistency in quality

Competitive lead times

Select off-the-shelf filters
Available with or without gamma irradiation

END-TO-END EXPERTISE

Leverage TFF expertise in filter selection and beyond

Selection of TFF format: Heavily reliant on modality
Screening membrane MWCO: Selection based on recovery and impurity removal
Final TFF condition optimization and sizing for process scale-up: Flux optimization and sizing at different scales

咨询专家

规模放大更加简单

中空纤维过滤器组件提供多种尺寸、表面积和膜材质选择，可轻松实现从小体积工艺开发和R&D应用到商品化生产的规模放大。规模放大时，维持过滤流路长度，增加纤维数量，即可提高过滤器的表面积，从而处理更大体积的料液。

	主要应用	体积	进口 / 出口	侧面端口	有效长度 (cm)	Total Length (cm)	Surface area
MicroKros
立即订购	Process characterization, Small-volume TFF in a laboratory	1-100 mL	MLL	FLL	20 41.5 65	25 45 69	13 – 20 cm² 26 - 59 cm² 41 - 92 cm²
MidiKros
立即订购	小规模工艺开发	100mL - 3L	FLL	FLL	20 41.5 65	25 45 69	75 – 190 cm² 155 - 390 cm² 245 - 610 cm²
MidiKros TC
立即订购	中试规模工艺开发	100mL - 3L	1/2" TC	FLL	20 41.5 65	25 45 69	75 – 190 cm² 155 - 390 cm² 245 - 610 cm²
MiniKros Sampler
立即订购	小体积批量TFF	3 L -15 L	0.75" TC	0.75" TC	20 41.5 65	25 47 70	490 – 1000 cm² 1000 - 2200 cm² 1600 - 3400 cm²
MiniKros
申请报价	中试规模TFF	5 L - 50 L	1.5" TC	0.75" TC	20 41.5 65	25 46 70	0.16 - 0.31 m² 0.32 - 0.65 m² 0.51 - 1.0 m²
KrosFlo^®
申请报价	生产规模TFF	10 – 100L	3" TC	1.5" TC	20 41.5 65	23 46 69	0.78 - 1.6 m² 1.65 - 3.25 m² 2.55 - 5.10 m²
KrosFlo^® MAX
申请报价	生产规模TFF	100L – 1000+L	6" TC	1.5" TC	49.9 67.9 107.5	73.5 91.5 131.1	4.30 - 10.40 m² 7.10 - 17.10 m² 11.30 - 11.35 m²