Repligen is revolutionizing how modern chromatography is performed. The result? Unprecedented recovery and operational efficiencies even with the most complex modalities.
Click on the image highlights to see key elements of chromatography redesigned.
Largest scale, broadest range
In response to the need to scale up chromatography processes, Repligen offers the largest pre-packed columns for the bioprocess industry. OPUS® 45R, 60R and 80R Columns are the first pre-packed columns designed to meet the chromatography requirements of larger 1000L and 2000L single-use bioreactors.
- Seamless scale-up from smaller OPUS® Columns
- VI级、EMA 410/01 合规材料
- GMP 和 pre-GMP 质量文件包
- ISO 文件 (CoA、RSF)
- 可选择填料 > 150 种
Packed with user-specified resins
Repligen 可装填来自>15 家填料供应商、60种填料家族的 > 250 种填料。最常装填的填料是粒径 30 - 120 μm，基于琼脂糖、甲基丙烯酸酯、纤维素和聚苯乙烯材料基质的填料。填料可由客户提供或由Repligen提供。可经批准后，提供便利的填料提取服务。
Repligen CaptivA® 和 CaptivA® HF
JSR Amsphere™ A3
ABT Rapid Run Agarose Bead (IEX)
Access CHT™ Resin pre-packed in OPUS Columns
Ceramic hydroxyapatite (CHT™) resin offers unique selectivity during the purification of mAbs and recombinant proteins. OPUS Columns can now be pre-packed with CHT™ resin and shipped world wide with excellent performance.
- 内径范围： 5 - 45 cm
- 柱床高度：5 - 30 cm
CHT™ 为 Bio-Rad Laboratories Inc. 注册商标
Innovative resin recovery port
With an innovative side port that allows for easy resin unpacking, OPUS 45R, 60R, and 80R Columns provide the ultimate flexibility in pre-packed column technology.
Without compromising chromatographic performance or cleanability, the new feature helps mitigate the risk of implementing pre-packed columns in GMP settings, and allows for re-use of the unpacked resin in other columns.
In the event of a deviation, and if the OPUS pre-packed column performance cannot be recovered, the column can be unpacked and the resin can be repacked into a traditional, self-packed column.
After the intended usage of the OPUS pre-packed column, the column can be unpacked and resin transferred to a development or pilot setting for additional use.
OPUS® 层析柱由医用级聚丙烯同聚物构成，所有产品接触表面均符合EMA 410/01 (或无动物源性)及VI级要求。
|2.5 - 30 柱管||聚丙烯|
|45 R- 80 R 层析柱管||70% w/w E-玻璃 / PP 工程复合结构|
|进口 / 出口||聚丙烯|
使用磷酸盐降低的色度检测显示，装填6 FF的 OPUS® 20层析柱可在仅2 CV内可靠地清除残留的磷酸盐。
- OPUS® 层析柱无显著的死腔
- OPUS® 层析柱设计易于清洗
Impact on process economics
Substantial savings in manufacturing costs and labor are realized because OPUS Columns offer the benefits that come with pre-packed technology:
In this example, over 65% cost savings and up to 80% labor savings were achieved when using OPUS Columns compared to self-packed columns.*
*Assumptions: OPUS 60R Pre-packed Column versus purchase of new 60 cm diameter automated self-pack equipment (columns are dedicated to a specific molecule). Data presented are estimates and subject to change.
OPUS® 2.5 - 80R Pre-packed GMP-ready Columns
OPUS® Pre-packed Chromatography Columns provide linear scale-up from process validation to commercial and GMP manufacturing. Select from the broadest portfolio of pre-packed GMP-ready column sizes, including large scale OPUS® 45R, 60R, and 80R Columns. Pre-packed columns enhance facility efficiency overall by converting column packing resources into productive chromatography and accelerating campaign turnaround time.
- Unpack resin using recovery port featured on OPUS® 45R, 60R and 80R columns
- 在ISO 7 级洁净室内装柱
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OPUS® Columns pack your choice of resin and the most precious element of all, time, into a self-packed ready-to-use chromatography column at almost any size and for almost every application. Skip months of hardware validation, execute more runs--and still leave work early to enjoy a bike ride. Don’t worry, we won’t tell your boss.
Reallocate column packing time and resources toward productive GMP-level chromatography, even at small-scale. The family of OPUS® Pre-packed Columns now includes the small but mighty OPUS® 2.5. Scale GMP purification effortlessly from 2.5 cm to 80 cm ID.