SoloVPE Application: Quantitation of Nucleic Acids (DNA/RNA)

The CTech™ SoloVPE® System has been proven to be accurate, precise, and robust for the quantitation of nucleic acids, such as DNA, RNA, and Oligonucleotide.

The Alternative to Traditional Spectrophotometric Analysis: Analysis for nucleic acid quantitation and purity assessment (DNA/RNA)

Analysis for nucleic acid quantitation and purity assessment

The emergence of different high absorbance biotherapeutics modalities, such as oligonucleotides, presents a challenge in using traditional spectrophotometric methods for concentration measurements. 

Slope Spectroscopy® offers an excellent alternative to traditional spectrophotometric analysis for nucleic acid quantitation and purity assessment using A260/A280 ratio measurement.

The SoloVPE Solution

  • Uses variable pathlength measurement data points to generate the slope within the linear region. 
  • Allows even highly concentrated samples to be measured without dilution and baseline correction. 
  • Saves time and produces reliable, reproducible results.

See Product


Application Services

Your success is our success

CTech is committed to our customers’ success. We design service offerings to supplement our standard support options and provide you with increased access to our highly knowledgeable and experienced professionals. We offer implementation, development, and educational guidance to maximize the benefits of your variable pathlength solutions and the Slope Spectroscopy® technique.

Application Services

  • 21 CFR Part 11 Guidance
  • Annex 11 Guidance
  • Validation Support
  • Qualification Service
  • Method Transfer Service


  • Method Design & Development
  • Comparability
  • On-Site Support
  • Custom Standards
  • Process Auditing


  • SOP Document Review
  • Advanced Slope Spectroscopy Training
  • Data Analysis
  • Maintenance & Troubleshooting