KrosFlo® KTF TFF Systems
Uniquely combining simplicity and configurability, Repligen KrosFlo® KTF Systems perform hollow fiber TFF to support multiple scales, unit operations, and solutions.
Single-use TFF Systems for Rapid Bioprocessing
See how Repligen systems for tangential flow filtration combine unparalleled configurability with premium quality manufacturing. System designs maximize scalability from small to large volumes, flexibility between hollow fiber and flat sheet filter formats, and ability to use the same system in different unit operations while deploying ready-to-use application-specific flow path assemblies.
可配置
Flexible across multiple parameters
KrosFlo® KTF Systems are configurable across multiple parameters, such as volume, application, and filter type. Multiple pumps of different sizes augment volume capability. Multiple pump types at different positions expand application and filter type support.
处理体积灵活性
- 可经配置用于各种批次体积
- 全面兼容 ProConnex® TFF 流路
- 管线 1 最高可支持 2500 L 处理体积 (KrosFlo® Max X06 过滤器)
- 管线 2 最高可支持 1000 L 处理体积 (KrosFlo® K06 过滤器)
应用灵活性
- 可经配置用于多种应用
- 针对 TFDF® 应用编程的iFIX软件
- 全面兼容 ProConnex® TFDF® 流路
- 管线 1 支持 UF/DF (1500 cm2)
- 管线 2 支持 UF/DF (6000 cm2)
可配置
Configure your KrosFlo® KTF System
Experience the ease and simplicity of designing on-line.
- 使用下拉菜单输入要求
- 一天内即可下载在线工程图
- 最快 6 周内即可发货，且产品即取即用
可配置
Configurable ProConnex® Flow Paths
ProConnex® 流路是用于切向流过滤的定制化、可配置的完整流路装置，其经工程设计过程而得以强化。该类流路装置可使用中空纤维和/或平板膜包TFF过滤器，在符合ISO指南的ISO 7级洁净室内生产，经预灭菌处理，适配于上游或下游处理应用。
ProConnex® Configurator
In minutes, using an online drag and drop configurator and with customer input, Repligen representatives can configure a ProConnex® Flow Path specific to a process application in real-time. The output of the ProConnex® Configurator are 3D engineering drawings and a preliminary quote, which greatly expedite the approval, production and delivery of the ProConnex® Flow Path.
integrated
Integrated to support multiple scales and applications
The fully integrated KrosFlo® KTF Systems consist of hardware, software and flow path components. Key hardware components include a digital peristaltic pump, auxiliary pumps and an automatic back pressure valve. Different combinations support multiple scales, unit operations and applications to maximize resource utilization.
Click on the tabs below to explore multiple systems to suit specific needs.
|
KrosFlo® KTF 200 |
KrosFlo® KTF 600 |
KrosFlo® KTF 1000 |
|
| 典型处理体积 | 可达200L | 可达1000L | 可达2500L |
| 最大过滤器面积 | 1.0 m2 (中空纤维) | 17.2 m2 (中空纤维) | 17.2 m2 (中空纤维) |
| 可配置的部件 | |||
| 泵 | MagLev x 1 (i100) | MagLev x 1 (600 系列) | MagLev x 1 (2000 系列) |
| 流速 | 泵 1：10 LPM | 泵 1：45 LPM | 泵 1：85 LPM |
| 最大压力 | 1.5 Bar | 2.0 Bar | 2.5 Bar |
| 最低滞留体积 | 200 mL | 2000 mL | 3500 mL |
| 与罐连接的管路 | 3/8" ID | 3/4" ID | 1" 和 3/4" ID |
| 中空纤维过滤器 | N 过滤器组件 | N、K、X 过滤器组件 | X 过滤器组件 |
| 回流流量计 | 外夹式超声波流量计 |
✓ |
✓ |
| 进样天平或客户信号 (4-20mA) |
台面 220kg | 台面 500kg、1000kg、2000kg | 平台 2000kg+ |
| 框架宽度 | 24" | 24" | 24" |
| TFF模式 | 浓缩、洗滤、最终浓缩、补料分批+ |
✓ |
✓ |
| 流路 | 无菌 ProConnex® 流路 |
✓ |
✓ |
| TMP控制 | 非侵入性阀 |
✓ |
✓ |
| 一次性使用压力传感器 | 卫生型 PS 0.5"、1.0"、1.38" |
✓ |
✓ |
| 框架 | 304不锈钢，<35Ra |
✓ |
✓ |
| 滤液泵 | 三辊轴蠕动泵 |
✓ |
✓ |
| 软件和HMI | |||
| HMI |
Rockwell 6181P HMI/Windows 10 | ✓ | ✓ |
| PLC | Allen Bradley Micrologix 1400 |
✓ |
✓ |
| 软件 | IFix 6.0 iHistorian Dream Reports E-signature |
✓ |
✓ |
| GMP | 可符合 21CFR11 |
✓ |
✓ |
| Delta V | 连接至 Delta V |
✓ |
✓ |
| 滤液流量计 | 外夹式或流通式超声波 |
✓ |
✓ |
|
|
KrosFlo® KTF 650 |
KrosFlo® KTF 700 |
KrosFlo® KTF 1600 |
KrosFlo® KTF 2000 |
| 典型处理体积 | 可达1000L | 可达1000L | 可达2500L | 可达5000L |
| 最大过滤器面积 | 17.2 m2 (中空纤维) | 17.2 m2 (中空纤维) | 17.2 m2 (中空纤维) | 17.2m2 (中空纤维) x 2 |
| 可配置的部件 | ||||
| 泵 | MagLev x 2 | MagLev x 2 | MagLev x 2 | MagLev x 2 |
| 流速 | 泵 1: 4 LPM 泵 2: 45 LPM |
泵 1: 10 LPM 泵 2: 45 LPM |
泵 1: 45 LPM 泵 2: 85 LPM |
泵 1 和 2：85 LPM |
| 最大压力 | 1.5 Bar | 2.0 Bar | 2.5 Bar | 2.5 Bar |
| 最低滞留体积 | 375 mL | 750 mL | 4500 mL | 6000 mL |
| 与罐连接的管路 | 1/4" 和 3/4" ID | 3/8" 和 3/4" ID | 1" 和 3/4" ID | 1" ID |
| 中空纤维过滤器 | T、S、N、K、X 过滤器组件 | S、N、K、X 过滤器组件 | K、X 过滤器组件 | X 过滤器组件 |
| 回流流量计 | 外夹式超声波流量计 |
✓ |
✓ |
✓ |
| 进样天平或客户信号 (4-20mA) |
台面 220kg、500kg、2000kg | Platform 200kg, 500kg, 2000kg | 平台 1000kg+ | 平台 2000kg+ |
| 框架宽度 | 30" | ✓ | ✓ | ✓ |
| TFF模式 | 浓缩、洗滤、最终浓缩、补料分批+ |
✓ |
✓ |
✓ |
| 流路 | 无菌 ProConnex® 流路 |
✓ |
✓ |
✓ |
| TMP控制 | 非侵入性阀 |
✓ |
✓ |
✓ |
| 一次性使用压力传感器 | 卫生型 PS 0.5"、1.0"、1.38" |
✓ |
✓ |
✓ |
| 框架 | 304不锈钢，<35Ra |
✓ |
✓ |
✓ |
| 滤液泵 | 三辊轴蠕动泵 |
✓ |
✓ |
✓ |
| 软件和HMI | ||||
| HMI | Rockwell 6181P HMI/Windows 10 | ✓ | ✓ | ✓ |
| PLC | Allen Bradley Micrologix 1400 |
✓ |
✓ |
✓ |
| 软件 | IFix 6.0 iHistorian Dream Reports E-signature |
✓ |
✓ |
✓ |
| GMP | 可符合 21CFR11 |
✓ |
✓ |
✓ |
| Delta V | 连接至 Delta V |
✓ |
✓ |
✓ |
| 滤液流量计 | 外夹式或流通式超声波 |
✓ |
✓ |
✓ |
integrated
Proprietary software and closed flow path support compliance and quality
|
|
|
|---|---|
| 基本控制平台 | iFIX 6.0 软件，300 个标签 |
| 批报告 | Dream Report® |
| 安全/趋势 | Windows® 10 ，含选配的 E-signature 及 iHistorian |
| PLC | Allen Bradley® PLC Micrologix 1400 |
| 通讯 | 指向iFIX：
|
| 界面选项 |
通过以太IP远程控制
|
| 法规 | 可符合21CFR11 要求 - 合规性和文件记录，包括审计追踪 |
| 工艺顺序 | 顺序根据工艺要求编程 |
READY TO SCALE FAST
Maintain processes while scaling to production
KrosFlo® KTF 200
KrosFlo® KTF 600
KrosFlo® KTF 2000
KrosFlo® KTF TFF Systems
KrosFlo KTF Systems include filters, ProConnex® Flow Path, pumps, process monitors, software and graphic display on a single skid, with a small footprint.
Click on the links below to explore different features.
解决方案
You know that horrible feeling of watching precious material go to waste? Get rid of it. Configure a low hold-up volume KrosFlo® KTF System and ProConnex® Flow Path and recover more product. Every time.
2021-06-16
01:34
The limitless design, exquisite accuracy and elegant simplicity of origami have been brought to TFF systems. Configure your optimal KTF KrosFlo® TFF system from the same starting point to satisfy your specific process needs. We have systems down to a science … and an art.
2021-03-19
01:44
Optimized for use with Repligen Hollow Fiber Filter Modules
Below is a list of compatible Hollow Fiber Filters for use with KrosFlo® KTF Systems.
| 主要 应用 |
体积 | 进口 / 出口 | 侧面 端口 |
标尺 长度 |
有效长度 (cm) | 总 长度 (cm) |
表 面积 |
|
|---|---|---|---|---|---|---|---|---|
MiniKros |
||||||||
 |
中试规模TFF | 5 L - 50 L | 1.5" TC | 0.75" TC | 1 x FL 2 x FL 3 x FL |
20 41.5 65 |
25 46 70 |
0.16 - 0.31 m2 0.32 - 0.65 m2 0.51 - 1.0 m2 |
KrosFlo® |
||||||||
 |
生产规模TFF | 10 – 100L | 3" TC | 1.5" TC | 1 x FL 2 x FL 3 x FL |
20 41.5 65 |
23 46 69 |
0.78 - 1.6 m2 1.65 - 3.25 m2 2.55 - 5.10 m2 |
KrosFlo® MAX |
||||||||
 |
生产规模TFF | 100L – 1000+L | 6" TC | 1.5" TC | R65 3 x FL R85 |
49.9 67.9 107.5 |
73.5 91.5 131.1 |
4.30 - 10.40 m2 7.10 - 17.10 m2 11.30 - 11.35 m2 |
Expert Project Management
客户至上。
Repligen DNA 为您提供支持。我们的目标是提供卓越的客户体验，并为所有 Repligen 产品和服务高效成功的采用及实施提供支持。
- Field Application Support
- 客户服务
- 现场服务工程师
KrosFlo® KR2i TFF System
Single-use fully integrated benchtop TFF system for use in lab scale process development ranging from 2mL - 15L. Compatible with hollow fiber or flat sheet filters, this system offers many user-defined set-point controls so you can run complex applications in fully-automated modes.
ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
资源
