XCell® ATF 系统
SIMPLIFY AND INTENSIFY
XCell® ATF Systems attach to a bioreactor to intensify upstream manufacturing capacity, productivity, and throughput.
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Intensification Leader
Intensification delivers more product faster
XCell ATF Technology helps simplify and intensify upstream processes to deliver more product, faster. Intensified processes achieve higher cell densities, require smaller bioreactors and consume less suite time. Increase throughput, productivity, and capacity in both clinical and commercial manufacturing.
INTENSIFICATION LEADER
XCellATF delivers 10X VCD and lower COGS
疟疾治疗候选药物的更高产量及更低产品成本。
- Can deliver 10X VCD more than 2-week Fed- Batch (350 x 106 cells/mL)
- 生物反应器运行时间降低50%
- 产量提高20倍
Breakthrough technology
How XCell ATF Technology Works
The XCell ATF System is based on award-winning alternating tangential flow (ATF) technology, created by the action of a diaphragm moving upward and downward within a pump head, connected to a filter housing and attached to a bioreactor. Alternating tangential flow is attained by the action of a diaphragm pump.
Breakthrough technology
Ready to scale from process development to manufacturing
The XCell ATF System simplifies and fast-tracks upstream intensification development from PD to commercial scale. Intensification increases throughput, accelerates tech transfer and optimizes your process in clinical manufacturing and MSAT while increasing bioreactor productivity and reducing costs in commercial manufacturing. Higher productivity, smaller bioreactors and higher throughput with shorter times to harvest, combine to mitigate facility expansion risks and capital costs.
整合式系统
Design simplicity with XCell® Lab System
Designed and engineered as a complete solution, the XCell Lab System integrates a modern controller, XCell ATF Devices, software and flow sensors into a complete solution.
- 精确工程设计的控制器，促进工艺强化
- Configurable set-up delivers high throughput - a single manifold supports up to 8 XCell ATF Devices
- 软件通过用户友好的界面，实现精确的技术控制
- New XCell ATF 1 Device is fit for low volume intensification ready for scale-up
- Repligen 全球技术支持可确保成功的技术实施和规模放大
XCell® LS Controller for Pilot and Commercial Manufacturing
Scaling up from bench scale to commercial scale can be simple with a reliable controller for vital cGMP operations
- Pairs with single-use and stainless steel XCell ATF 6 and XCell ATF 10 devices, and the stainless steel XCell ATF 4 device
- Single LS Controller controls single or dual ATF devices at once
- Advanced process monitoring: flow sensor-based control, permeate pressure sensing/filter fouling
- Intuitive software with touchscreen interface, 21 CFR part 11 compliant, and Windows 10 Domain security
- Operate independently with HMI or integrate with site DCS systems (headless configuration)
- Global technical support ensures successful implementation and scale-up
XCell ATF 设备和控制器
The XCell ATF System delivers a complete solution for upstream intensification with robust hardware software integration. Available in single-use and stainless steel formats with sizes from lab-scale (2 L) to process scale (5000 L). Each system consists of an XCell ATF Device, XCell Controller, software, tubing and sensors.
XCell ATF Systems
XCell ATF Cell retention technology simplifies and fast-tracks upstream intensification development for gene therapy, fed-batch intensification, seed train intensification, perfusion, and media exchange applications.
The XCell™ Lab Controller solves your productivity puzzle with new engineering, increased throughput and more process data. Turn the frustration of endless permutations into a simple solution that generates more cells, and more product…faster.
2021-04-21
01:40
Intensification is worth it. Build an intensified upstream suite brick by brick with XCell ATF® systems. Make twice as much product in half the time as you watch VCD grow and shrink bioreactor sizes within the same facility footprint.
2020-12-14
01:45
OMG life gets busy. Set-up industry-best cell culture intensification in less than 30 minutes with the design simplicity of XCell ATF® devices. Celebrate more product at work…and still have time for the special moments at home. YGTI.
2021-08-27
01:50
客户至上。
Repligen DNA 为您提供支持。我们的目标是提供卓越的客户体验，并为所有 Repligen 产品和服务高效成功的采用及实施提供支持。
- Field Application Support
- 客户服务
- 现场服务工程师
资源
Investigation of XCell ATF® Perfusion Technology for virus manufacturing process intensification at MSD Animal Health
Repligen Corporation
MSD Animal Health
7月，2022
规格
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XCell® ATF 1 |
XCell® ATF 2 |
XCell® ATF 4 |
XCell® ATF 6 | XCell® ATF 10 | ||
| Typical Bioreactor size (L) | 0.5 - 2 | 2-10 | 10-50 | 50-200 | 200-5000 | |
| Format | SU | SU, SS | SS | SU, SS | SU, SS | |
| Chemistry | PES | PES, PS | PES, PS | PES, PS | PES, PS | |
| Typical pore size SU | 0.2µ | 0.2µ | 0.2µ | 0.2µ | 0.2µ | |
| Typical pore size SS | NA | 0.2µ, 0.5µ, 50KDa | 0.2µ, 0.5µ, 50KDa | 0.2µ, 0.5µ, 50KDa | 0.2µ, 0.5µ, 50KDa | |
| Effective surface area (m2) | 0.022 | 0.13 | 0.77 | 2.5 | 11 | |
| Filter height (cm) | 60 | 60 | 30 | 60 | 60 | |
| Displacement volume (L) | 0.017 | 0.1 | 0.4 | 1.3 | 6 | |
| ATF flow range (Lpm) | 0.008 - 0.140 | 0.4 - 1.5 | 3-8 | 10-20 | 30-80 | |
| Typical scalable flow/fiber and filtrate rate | 12 mL/min/fiber and 4-6 LMH | |||||
| 控制器 | Lab Scale Controller |
Lab Scale Controller |
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