TangenX® PRO Cassettes
Designed to be cleaned and re-used multiple times, PRO and PRO PD Reusable TFF Cassettes are interchangeable with SIUS® Single-use Cassettes.
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TangenX® PRO Reusable TFF Cassettes may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.
FLEXIBLE
Diverse options for diverse process needs
PRO TFF Cassettes are offered with two membrane chemistries, two screen types, a wide selection of molecular weight cutoffs (MWCO), and a broad range of surface areas. With 96 configurations available, PRO TFF Cassettes accommodate diverse process requirements for ultrafiltration and diafiltration applications from process development to commercial manufacturing.
- 中性电荷
- 低蛋白结合
- 出色的化学耐受性
- 亲水性
- 低蛋白结合
- 疏水性物质污染最小化
Screens
FLEXIBLE
Multiple channel configurations
Tangential flow filtration cassettes create turbulence at the membrane's surface and minimize fouling. The result is an increase in performance with a higher permeate flux. PRO Cassettes are offered in three different channel configurations to best suit the application. The channel configuration refers to the type of turbulence promoter incorporated into the feed channel of a cassette.
A medium channel or L screen is offered in all PRO Cassette formats. The screen creates turbulence at the membrane's surface ensuring outstanding permeate flux with minimal fouling. This channel configuration requires the lowest pumping rate and yields the highest cross flow velocity. This type of channel is best suited for clarified feed streams over a wide range of viscosities.
A coarser screen channel, the EP channel is offered in all PRO Cassettes. The screen geometry of this single-use cassette can process feed streams with a higher viscosity and reduce the overall pressure drop. It is scalable from 100cm2 to 2.5m2, packaged sanitized and compatible with existing cassette holders and FPIs. This type of channel is best suited for processes that use shear sensitive feed streams.
An open channel or J channel is offered in all PRO Cassettes. A 0.5mm flow spacer separating the membrane creates an open feed flow channel. This type of channel creates the least amount of turbulence while still minimizing fouling. It also requires the highest pumping rate to pass particulates. This type of channel is best suited for unclarified feed streams and is used for processes such as cell harvest operation.
FLEXIBLE
Compatible with most cassette holders
To ensure fit with cassette holders from other manufacturers,
PRO TFF Cassettes for process development are offered with two different notch patterns at the end of the cassette.
TangenX® PRO PD with standard notch
0.850in (21.59mm) Offset
这种构型可匹配下列膜包卡盘和夹具：
- TangenX® SIUS® PD Cassette Clamps
- TangenX® PRO PD Cassette Holders
- Pall - Centramate 夹具 (CM018LV、FS001K10)
TangenX® PRO PD with offset notch
0.756in (19.21mm) 偏置
这种构型可匹配下列膜包卡盘和夹具：
- 这种构型可匹配以下第三方膜包夹具：
- Sartorius - Sartocon Slice 夹具 (17525-01、17521-02)
- GE - Kvick Lab 夹具 (KLPH01SSU、KLHR0105000SS)
- Millipore - Pellicon Mini 夹具 (XX42PMINI)
可放大性
可从工艺开发规模放大至商品化生产
Process volume and membrane area determine scale-up from SIUS® Single-use Cassettes to PRO Reusable TFF Cassettes.
Single-use TFF provides the greatest benefit for small to moderate scale operations.
Reusable TFF is optimal for large production scale operations.
Interested in simulating a cost model for your specific application?
TangenX® PRO Cassettes
TangenX® PRO Reusable TFF Cassettes may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.
Validated for GMP use, PRO TFF Cassettes come in two industry standard format footprints with accompanying holders. They are available using ProStream or HyStream membranes, with choice of pore size and flow-channel configuration.
Click on the tabs below to explore different features of PRO Cassettes for process development or commercial manufacturing.
During process development, scientists aim to select the most promising membrane candidates, while making related decisions regarding feed pressure, TMP and screen geometry. PRO PD Cassettes enable process development scientists to select the most promising membrane candidates.
Membrane Surface Areas:
0.01 meter2, 0.02 meter2, 0.10 meter2
When the primary membrane candidate has already been chosen as a process parameter, the production method needs to be verified and production materials produced for toxicology or pre-clinical trials, and ultimately for large-scale commercial production. TangenX® PRO TFF Cassettes provide reliable cassette-to-cassette consistency, ensuring that processes can scale to commercial production levels.
Membrane Surface Areas:
0.5 meter2, 1.5 meter2, 2.5 meter2
解决方案
TFF genius
You’re not asking for too much. Combine high selectivity and reduced processing time. Become a TFF genius and get it all with TangenX® Membranes and TFF Devices.
经验证的生产过程
高质量生产
TangenX® Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP. Each cassette comes with a Quality Assurance Certificate.
完整法规支持文件
Each TangenX® TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:
- 产品信息
- 膜包设计
- 结构材料
- 产品性能
- 安全信息
- 文件系统
- 产品生产
- 质量确认
- 生产工艺验证
- 出厂检测
客户至上。
Repligen DNA 为您提供支持。我们的目标是提供卓越的客户体验，并为所有 Repligen 产品和服务高效成功的采用及实施提供支持。
- Field Application Support
- 客户服务
- 现场服务工程师
TangenX® PRO Hardware
TX003 (中试夹具)
- 经扩展设计，可容纳 0.01 - 0.5 m2 (1 - 5 ft2) 筛网流道或悬浮筛网流道膜包
- 提供鲁尔锁接头形式，以降低滞留体积，或迷你TC接头形式，以用于卫生型应用
TX034 (带支架和3-压力表接头套装的HC-LHV 夹具)
- 增强可排放性
- 降低占地，高效利用有限的实验室空间
TX032 (水平卫生型夹具，第2版)
- 经扩展设计，可容纳 0.46 - 6 m2 (% - 50 ft2) 筛网流道或悬浮筛网流道膜包
- 更小的占地即意味着更低的投入及运营成本，可高效利用有限的生产空间
TX005 (带自动扭矩的垂直卫生型夹具)
- 增强可排放性
- 提供液压自动扭矩锁紧选择
- 最大限度降低安装大面积系统时的难度和时间
- 避免膜包不对齐及潜在的泄漏风险
- 单面垂直设计可轻松安装和更换膜包
- 避免操作员扭矩拧紧差异
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KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
TangenX® SIUS® TFF Cassettes
SIUS® Cassettes are the first purpose-built single-use cassettes for tangential flow filtration, delivering unparalleled savings in filter cost, labor cost and buffer use.
TangenX SC TFF Device
TangenX® SC TFF Device: Revolutionize tangential flow filtration processes
Eliminate the hassle and inefficiency that comes with traditional downstream filtration cassette formats. Say goodbye to cassette holders, complex setups, continued torquing, wasted time, and product loss risks. Discover TangenX® SC, the future of TFF cassette solutions for ultrafiltration and diafiltration, designed to meet the demands of today’s TFF processes while dramatically reducing setup time and minimizing product loss risk.
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