XCell® ATF Devices and Controllers
XCell® ATF Systems simplify and fast-track upstream intensification by providing an integrated solution consisting of an XCell® ATF Device, XCell® ATF Controller, software, tubing, pressure sensors and accessories. The family of Systems supports diverse applications across development from 1L to 5000 L.
XCell® ATF Device Size Selection Guide
Presented are hollow fiber filter areas, XCell® ATF Pump volumes, and typical bioreactor working volumes paired with each XCell ATF Device. Actual capacity and vessel size depend upon specific cell culture process conditions.
XCell® ATF Single-use Devices
XCell ATF 1 Single-use Device
XCell ATF 2 Single-use Device
XCell ATF 6 Single-use Device
XCell ATF 10 Single-use Device
XCell ATF Single-use Tubing Sets
过滤器润湿程序
XCell ATF Single-use Devices are supplied dry. To ensure robust filter performance, it is important to wet the filter prior to use. The XCell ATF Tubing Set and the suggested wetting protocols are designed to:
- 降低润湿过程中气泡的形成,以确保过滤器被有效且完全地润湿
- 方便进行使用前过滤器完整性测试,同时维持无菌性
- Provide a means for evaluating the sterility of the XCell ATF device prior to establishing the bioreactor connection
- Allow change-out of the XCell ATF device during a cell culture run without interrupting the bioreactor or XCell ATF operation
XCell ATF Stainless Steel Devices
XCell ATF 2 Stainless Steel Device
XCell ATF 4 Stainless Steel Device
XCell ATF 6 Stainless Steel Device
XCell ATF 10 Stainless Steel Device
如何安装中空纤维过滤器
Watch the video on how to install a hollow fiber filter into an XCell ATF 10 stainless steel device.
XCell® Controllers
XCell Lab Controller
for use with:
XCell ATF 1 (SU)
XCell ATF 2 (SU,SS)
XCell ATF 4 (SS)
XCell LS Controller
for use with:
XCell ATF 4 (SS)
XCell ATF 6 (SU, SS)
XCell ATF 10 (SU, SS)
XCell C410 Controller
for use with:
XCell ATF 4 (SS)
XCell ATF 6 (SU, SS)
XCell ATF 10 (SU, SS)
XCell C410 Controller Cart
(optional)
Advancing Upstream Intensification Through Partnership
Repligen has partnered with Sartorius to integrate the XCell® ATF large scale controller technology into the Biostat 3G STR® bioreactor to advance Upstream Intensification for biopharmaceutical manufacturers.
XCell ATF devices by scale
XCell® ATF 1 |
XCell® ATF 2 |
XCell® ATF 4 |
||
---|---|---|---|---|
Typical Bioreactor size (L) | 0.5 - 2 | 2-10 | 10-50 | |
Format | SU | SU, SS | SS | |
Chemistry | PES | PES, PS | PES, PS | |
Typical pore size SU | 0.2µ | 0.2µ | 0.2µ | |
Typical pore size SS | NA | 0.2µ, 0.5µ, 50KDa | 0.2µ, 0.5µ, 50KDa | |
Effective surface area (m2) | 0.022 | 0.13 | 0.77 | |
Filter height (cm) | 60 | 60 | 30 | |
Displacement volume (L) | 0.017 | 0.1 | 0.4 | |
ATF flow range (Lpm) | 0.008 - 0.140 | 0.4 - 1.5 | 3-8 | |
Typical scalable flow/fiber and filtrate rate | 12 mL/min/fiber and 4-6 LMH | |||
控制器 | XCell Lab Scale Controller |
|
XCell® ATF 4 |
XCell® ATF 6 |
|
---|---|---|
Typical Bioreactor size (L) | 10-50 | 50-200 |
Format | SS | SU, SS |
Chemistry | PES, PS | PES, PS |
Typical pore size SU | 0.2µ | 0.2µ |
Typical pore size SS | 0.2µ, 0.5µ, 50KDa | 0.2µ, 0.5µ, 50KDa |
Effective surface area (m2) | 0.77 | 2.5 |
Filter height (cm) | 30 | 60 |
Displacement volume (L) | 0.4 | 1.3 |
ATF flow range (Lpm) | 3-8 | 10-20 |
Typical scalable flow/fiber and filtrate rate | ||
控制器 |
|
|
XCell® ATF 6 |
XCell® ATF 10 |
||
---|---|---|---|
Typical Bioreactor size (L) | 50-200 | 200-5000 | |
Format | SU, SS | SU, SS | |
Chemistry | PES, PS | PES, PS | |
Typical pore size SU | 0.2µ | 0.2µ | |
Typical pore size SS | 0.2µ, 0.5µ, 50KDa | 0.2µ, 0.5µ, 50KDa | |
Effective surface area (m2) | 2.5 | 11 | |
Filter height (cm) | 60 | 60 | |
Displacement volume (L) | 1.3 | 6 | |
ATF flow range (Lpm) | 10-20 | 30-80 | |
Typical scalable flow/fiber and filtrate rate | 12 mL/min/fiber and 4-6 LMH | 12 mL/min/fiber and 4-6 LMH | |
控制器 |
|
|
资源
Investigation of XCell ATF® Perfusion Technology for virus manufacturing process intensification at MSD Animal Health
Repligen Corporation
MSD Animal Health
7月,2022