KrosFlo® KR2i TFF System
Single-use fully integrated benchtop TFF system for research and process development (PD) ranging from 2mL - 15L. Compatible with hollow fiber and flat sheet filters, this system features a peristaltic feed pump with 13 automated process modes.
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Robust Processing
Ultrafiltration and diafiltration (UF/DF) processing for batch volumes ranging 2mL to 15L.
简单易用
Plug and play configurability to add and remove components as needed with minimal effort.
Compatible with flat sheet cassettes and hollow fiber filters.
Walk-away automation
13 automated process control modes with the Automatic Back Pressure Valve (ABV) and intuitive software platform.
Off-the-shelf flow paths
Gamma irradiated, single-use, ProConnex® flow paths for enhanced reproducibility, time savings and sterility.
Modularity Made Easy with Plug-and-Play Configurability
KrosFlo® KR2i TFF systems achieve an unparalleled combination of configurability and user-simplicity through modular, plug-and-play hardware. All components, either directly or indirectly, connect to the main pump, which then communicates with the KF Comm 2 software for control and monitoring.
More Capabilities, Still Simple.
Get more out of TFF with the flexibility to configure your system to better suit your application needs. Keep your process compact and minimal or expand your capabilities to more advance modes of operation by adding components. Switch back and forth between configurations all without compromising on ease of use.
Automate, Control and Visualize with KF Comm 2
Control the whole system, configure recipes and automate processes in as little as 4 clicks through the intuitive KF Comm 2 software.
- Conveniently installed on any device using the Windows Operating System
- Compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers
- Automatic software and firmware updates
- Optional 21 CFR Part 11 package available
仍在使用旧版KF Comm软件？ Upgrade now
Walk-away automation for your lab
The days of manually adjusting screw clamps are over. A Repligen-exclusive technology, the Automatic Back Pressure (ABV) Valve adds transmembrane pressure (TMP) control to every TFF process, reducing operator hands-on-time, data logging and continuous monitoring while improving process reproducibility.
- Automatically adjust tubing pinch distance according to user-defined set-points
- Maintain uniform TMP throughout process run, decreasing membrane fouling
- 使用兼容管号：13、 14、 16、 25、 HP15、 17、 HP24、 18、 HP35、 36 和 HP36
具备在线蛋白质浓度管理功能的 TFF
No longer are you dependent solely on mass inputs and off-line fixed-pathlength UV-Vis spectrophotometers. Now, you can measure what truly matters in real-time with the KrosFlo® KR2i RPM™ System. Monitor concentration in real time during your UF/DF run and control your process.
KrosFlo KR2i Virtual Demo Series
In this 6-part series, Julie Grace, and Carl Breuning, provide viewers with a virtual training on the KrosFlo® KR2i TFF system. This training series will cover the following topics:
- Introduction to system components
- Installation of flow-path and filter
- KF Comm2 software overview
- Recipe creation
- Running a CFC/D/C experiment
- Recovery of product
KrosFlo® KR2i Virtual Demo Series
Whether you’re new to this TFF system or in need of a refresher, this virtual demo series will show how easy it is to set up and operate a KrosFlo KR2i. This training series will cover the following topics:
- Introduction to system components
- Installation of flow-path and filter
- KF Comm2 software overview
- Recipe creation
- Running a CFC/D/C experiment
- Recovery of product
Standard and Configurable ProConnex® Flow Paths
ProConnex® Flow Paths are customized, configurable and complete assemblies for tangential flow filtration. Designed for use with hollow fiber and/or flat sheet TFF systems, the assemblies are sterile, fit for upstream or downstream processing and manufactured in compliance with ISO guidelines in an ISO 7 clean room.
Effortless scaling with a single standardized platform
Designed as a platform and not as standalone units, KrosFlo KR2i, KMPi, and FS lab scale TFF systems share the same components, software and controls across the entire family, allowing you to confidently standardize your process. Common process change challenges during scale-up are removed.
System features at a glance
The fully integrated KrosFlo KR2i TFF System features a digital peristaltic pump, graphical LCD display, digital pressure monitor, KR2i Pump head, automatic backpressure valve, filter module stand, and KF Comm real-time data collection software.
Highly configurable and versatile, the KrosFlo KR2i utilizes a number user-defined set-points to run complex application processes with numerous built-in safety alarms and stops. The system can run up to two stackable pump heads for higher flow rates.
Click on the links below to explore different features.
部件和配件
- IP 33 级外壳
- 600 RPM 泵，带可逆驱动
- 90-260 Vrms @ 50/60 Hz
- 标准 Easy Load 3 泵头，适用高精度13、14、16、25、17 和 18 号L/S管。
- (选配) Easy Load 3 泵头，适用高性能15、24、35、36号L/S管。
- ETL注册，带CE/UL/cUL标识
- 泵驱动尺寸：10.5 in x 8 in x 8 in
KONDUiT可增加：
- 用于UF/DF的终点电导控制
- 用于从药物递送颗粒中洗滤去除游离药物的终点UV控制
- 用于特定分子浓缩时的终点UV控制
- 用于膜穿透的UV警报
- 提供A260 和 A280 光源
*UV 部件单独销售
Related products
KrosFlo® KTF TFF Systems
The KrosFlo KTF are a series of highly configurable single-use TFF systems for multiple unit operations, applications, and filter types. With volumes spanning across 1 to 5000L, users enjoy the unrivaled flexibility of processing large and small batch sizes within the same platform.
KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
Process Analytics
Our process analytics solutions, featuring Variable Pathlength Spectroscopy for at-line and in-line concentration monitoring systems, ensure that products meet required Process Analytical Technology (PAT) standards. These tools provide critical data for optimizing bioprocesses and ensuring compliance with regulatory requirements.
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