Downstream Processing and New Modalities

Wädenswil, Switzerland


Institute of Chemistry and Biotechnology
ZHAW School of Life Sciences and Facility Management
Grüentalstrasse 14, P.O. Box
8820 Wädenswil

Innovative chromatography and TFF system technology, resin science breakthroughs, fluid management innovations, and real-time process management have improved traditional downstream process economics and efficiencies for all separation techniques with focus on gene therapy and new modalities. Join us for a one-day workshop that starts with classroom discussion on industry trends towards single-use technology and wraps with a demonstration of the Repligen technologies in a laboratory setting.



8:30 - 9:00 coffee and registration
9:00 - 9:30 Welcome and introduction
9:30 - 11:00 Why single use downstream processing technology? How does it work?
11:00 - 11:30 Break and move to lab
11:30 - 12:30 Practical session 1 in the lab: KrosFlo® TFF System / KRM™ Chromatography System
12:30 - 13:15 Business Lunch
13:15 - 13:45 Common software platform
13:45 - 14:15 Case Study: Single-use tangential flow system design and control ensures diafiltration
14:15 - 15:15 Practical session 2 in the lab: KrosFlo® TFF System / KRM™ Chromatography System
15:15 - 15:45 Break and move back to classroom
15:45 - 16:00 Fluid management how to connect operation Units
16:00 - 16:45 Case studies: Increasing AAV recovery with new chromatography system technologies
16:45 - 17:00 Analytics KrosFlo® KR2i RPM™ System
17:00 Wrap up and closing