Intensification starts here!

KrosFlo® Tangential flow depth filtration (TFDF®) techology is used to overcoming cell density and productivity challenges with virus production, manufacturing while streamlining the clarification process, offering a simplified alternative to batch cell culture methods.


  • Increase virus productivity
  • Higher virus recovery 
  • Better throughput clarification



Intensified AAV Production with TFDF®-based Perfusion Cell Culture

This article will examine the implementation of TFDF-based perfusion cell culture for viral vector production can limit the cell density effect, and, therefore, intensify the virus production compared to current batch processes.


Simplified Lentivirus and AAV clarification with TFDF®-based intensified virus production

In this paper we will look at how KrosFlo® TFDF® based process intensification leads to high virus production combined with simplified clarification compared to batch cell culture.