KrosFlo® KR2i TFF System

A turnkey benchtop system for 2 ml - 15 L lab-scale process development, the KrosFlo^®KR2i TFF System with peristaltic pump is fully integrated and easy to use with walkaway automation.

Why it matters 关于相关产品资源

申请报价

整合式

Introducing KrosFlo® Kr2i RPM System

Complete turnkey TFF system

Configurable ProConnex^® Flow Paths

AUTOMATED

Menu-driven software

Automatic Back Pressure control valve

Monitor conductivity, UV and temperature

可放大性

Scale from 1-5000 L with compatible KrosFlo^® TFF Systems

INTEGRATED

The First Time is the Right Time with

the KrosFlo^® KR2i RPM™ System

Finally, a Tangential Flow Filtration (TFF) system that monitors concentration during your UF/DF run. No longer are you dependent solely on mass inputs and off-line fixed-pathlength UV-Vis spectrophotometers. Now, you can measure what truly matters in real-time, your concentration.

从这里开始

INTEGRATED

Complete, Turnkey TFF System

Fully integrated and ready to use out of the box, the KrosFlo^® KR2i enables faster process development facilitating multiple tests/processes, accurate process definition and execution consistency. The system includes precise and reproducible control and documentation of TFF processes with volumes from 2mL to 15L, and filtration areas from 13 cm² to 5000 cm².

INTEGRATED

Configurable ProConnex® Flow Paths

ProConnex^® 流路是用于切向流过滤的定制化、可配置的完整流路装置，其经工程设计过程而得以强化。该类流路装置可使用中空纤维和/或平板膜包TFF过滤器，在符合ISO指南的ISO 7级洁净室内生产，经预灭菌处理，适配于上游或下游处理应用。

PROCONNEX^® FLOW PATHS

AUTOMATED

Menu-driven Software

KF Comm 2 Software, backward compatible with legacy KrosFlo^® KR2i and KrosFlo^® KMPi Systems, is conveniently installed on any computer using the Windows Operating System. The software is compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers and is always current with automatic software and firmware updates.

用于KrosFlo^®TFF 系统的专利软件
提供21CFR Part 11合规版本，以验证用于GMP工艺
直观的工作流，13种操作模式

KF Comm 2 软件

AUTOMATED

自动背压控制阀

Repligen独家技术，自动背压控制阀为每个TFF工艺增加跨膜压（TMP）控制，减少操作员手动操作时间，提高工艺可再现性。

按用户设置的设定点，自动调整管夹距离
在整个工艺运行过程中，维持均一的TMP，降低膜污染
在微滤应用中，控制滤液压力和流速
使用兼容管号：13、 14、 16、 25、 HP15、 17、 HP24、 18、 HP35、 36 和 HP36
可用于自动调节进样、回流、滤液或跨膜压力

AUTOMATED

Monitor and evaluate conductivity, UV and temperature

Konduit is an add-on module ready to use with the KrosFlo^® KR2i and KMPi TFF Systems, with the ability to scale from 2mL to 500L process volumes.

电导率范围	0.1 - 100 mS/cm
温度范围	0-70°
压力范围	可达 75 psi (5 bar)
尺寸	(L x W x H): 7¾" x 4¾" x 4½"
重量	1.6 kg

READY TO SCALE FAST

Scalable From Lab-scale to Process-scale

The KrosFlo^® family of TFF Systems for concentration and diafiltration supports scale up from process development to commercial manufacturing.

KrosFlo^® KR2i System
2ml - 15L

KrosFlo® KMPi System
100mL - 500L

KrosFlo^® KTF Systems
10L - 2000L+

KrosFlo® KR2i TFF System

The fully integrated KrosFlo^® KR2i TFF System features a digital peristaltic pump, graphical LCD display, digital pressure monitor, KR2i Pump head, automatic backpressure valve, filter module stand, and KF Comm real-time data collection software.

Highly configurable and versatile, the KrosFlo^® KR2i utilizes a number user-defined set-points to run complex application processes with numerous built-in safety alarms and stops. The system can run up to two stackable pump heads for higher flow rates.

Click on the links below to explore different features.

UF/DF

Process Management

Optimized for use with Repligen Hollow Fiber Filter Modules

	主要应用	体积	进口 / 出口	侧面端口	标尺长度	有效长度 (cm)	总长度 (cm)	表面积
MicroKros	实验室规模工艺表征、小体积 TFF 处理	1-100 mL	MLL	FLL	1 x FL 2 x FL 3 x FL	20 41.5 65	25 45 69	13 – 20 cm² 26 - 59 cm² 41 - 92 cm²
MidiKros	小规模工艺开发	100mL - 3L	FLL	FLL	1 x FL 2 x FL 3 x FL	20 41.5 65	25 45 69	75 – 190 cm² 155 - 390 cm² 245 - 610 cm²
MidiKros TC	中试规模工艺开发	100mL - 3L	1/2" TC	FLL	1 x FL 2 x FL 3 x FL	20 41.5 65	25 45 69	75 – 190 cm² 155 - 390 cm² 245 - 610 cm²
MiniKros Sampler	小体积批量TFF	3 L -15 L	0.75" TC	0.75" TC	1 x FL 2 x FL 3 x FL	20 41.5 65	25 47 70	490 – 1000 cm² 1000 - 2200 cm² 1600 - 3400 cm²

查找 KrosFlo^® 产品

部件和配件

RGEN

Manufacturing Centers of Excellence

Repligen在ISO 9001质量管理体系下开发和生产用于生物制药行业的产品。我们专注于及时交付高质量、一致且稳健的产品，以确保我们客户的业务连续性。

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands, Germany and Estonia.

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